Rigid-Rod ß-Barrels with Internal &quot;&quot;Cascade Blue&quot;&quot; Cofactors - Catalysis of Amide, Carbonate and Ester Hydrolysis

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Title		Rigid-Rod ß-Barrels with Internal ""Cascade Blue"" Cofactors - Catalysis of Amide, Carbonate and Ester Hydrolysis
Authors		Som, Abhigyan Matile, Stefan
Published in		European Journal of Organic Chemistry. 2002, vol. 2002, no. 22, p. 3874-3883
Abstract		The pyrene-1,3,6-trisulfonate scaffold is introduced as an internal cofactor for histidine-rich p-octiphenyl ß-barrels with catalytic and ion channel activity to mediate binding and conversion of otherwise inaccessible benzaldehyde substrates. Up to 170,000-fold accelerations of amide, ester, and carbonate hydrolysis, high substrate diversity, high chemoselectivity, and absence of enantioselectivity are reported.
Keywords		Bioorganic chemistry — Catalysis — Ion channels — Molecular recognition — Supramolecular chemistry
Identifiers		DOI: 10.1002/1099-0690(200211)2002:22<3874::AID-EJOC3874>3.0.CO;2-6
Full text		Article - Limited access to UNIGE
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation (ISO format)		SOM, Abhigyan, MATILE, Stefan. Rigid-Rod ß-Barrels with Internal ""Cascade Blue"" Cofactors - Catalysis of Amide, Carbonate and Ester Hydrolysis. In: European Journal of Organic Chemistry, 2002, vol. 2002, n° 22, p. 3874-3883. doi: 10.1002/1099-0690(200211)2002:22<3874::AID-EJOC3874>3.0.CO;2-6 https://archive-ouverte.unige.ch/unige:7784

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Deposited on : 2010-06-21

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