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Title

Rigid-Rod ß-Barrels with Internal ""Cascade Blue"" Cofactors - Catalysis of Amide, Carbonate and Ester Hydrolysis
Authors
Som, Abhigyan
Matile, Stefan
Published in European Journal of Organic Chemistry. 2002, vol. 2002, no. 22, p. 3874-3883
Abstract The pyrene-1,3,6-trisulfonate scaffold is introduced as an internal cofactor for histidine-rich p-octiphenyl ß-barrels with catalytic and ion channel activity to mediate binding and conversion of otherwise inaccessible benzaldehyde substrates. Up to 170,000-fold accelerations of amide, ester, and carbonate hydrolysis, high substrate diversity, high chemoselectivity, and absence of enantioselectivity are reported.
Keywords Bioorganic chemistry — Catalysis — Ion channels — Molecular recognition — Supramolecular chemistry
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Article - document accessible for UNIGE members only Limited access to UNIGE
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Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation
(ISO format) 		SOM, Abhigyan, MATILE, Stefan. Rigid-Rod ß-Barrels with Internal ""Cascade Blue"" Cofactors - Catalysis of Amide, Carbonate and Ester Hydrolysis. In: European Journal of Organic Chemistry, 2002, vol. 2002, n° 22, p. 3874-3883. https://archive-ouverte.unige.ch/unige:7784

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Deposited on : 2010-06-21

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