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Optogénétique : ouvrir de nouveaux horizons thérapeutiques dans la stimulation cérébrale profonde

Davoine, Elise
Bellone, Carmilla
Published in Revue médicale suisse. 2015, vol. 11, no. 472, p. 987-991
Abstract For the last decade, optogenetics has revolutionised the neurosciences by enabling an unprecedented characterisation of the circuits involved in brain diseases, in particular addiction, depression, and obsessive compulsive disorders (OCD) and other anxiety disorders. Recently, the technique has also been used to propose blueprints for novel treatments of these diseases. For many reasons, optogenetics cannot be applied to humans applications anytime soon; we therefore argue that an intermediate step would be novel deep brain stimulation (DBS) protocols that emulate successful optogenetic "treatments" in animal models. Here we provide a roadmap of a translational path to rational, optogenetically inspired DBS protocols to refine existing approaches and expand it to novel indications.
Keywords AnimalsAnxiety Disorders/therapyDeep Brain Stimulation/methodsDepression/therapyHumansObsessive-Compulsive Disorder/therapyOptogenetics/methodsSubstance-Related Disorders/therapyTranslational Medical Research/methods
PMID: 26062226
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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LUSCHER, Christian, DAVOINE, Elise, BELLONE, Carmilla. Optogénétique : ouvrir de nouveaux horizons thérapeutiques dans la stimulation cérébrale profonde. In: Revue médicale suisse, 2015, vol. 11, n° 472, p. 987-991. https://archive-ouverte.unige.ch/unige:77668

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Deposited on : 2015-11-25

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