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On the Electrostatics of Cell Membrane Recognition: From Natural Antibiotics to Rigid Push-Pull Rods

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Published in Chemistry - A European Journal. 2000, vol. 6, no. 10, p. 1731-1737
Abstract The question why pore-forming, α-helical natural antibiotics are not toxic is discussed within the general context of the interaction of electrostatically asymmetric nanorods with neutral, anionic, and polarized bilayer membranes. We suggest that simplification of the structural complexity of natural systems will be necessary to ultimately define the involved subtle balance between constructive and destructive electrostatic interactions.
Keywords AntibioticsIon channelsMembranesMolecular recognitionPeptidomimetics
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SAKAI, Naomi, MATILE, Stefan. On the Electrostatics of Cell Membrane Recognition: From Natural Antibiotics to Rigid Push-Pull Rods. In: Chemistry - A European Journal, 2000, vol. 6, n° 10, p. 1731-1737. https://archive-ouverte.unige.ch/unige:7765

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Deposited on : 2010-06-21

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