UNIGE document Scientific Article
previous document  unige:7763  next document
add to browser collection

Ligand-Gated Synthetic Ion Channels

Published in Chemistry - A European Journal. 2005, vol. 11, no. 22, p. 6525-6532
Abstract Supramolecular pi-stack architecture is fundamental in DNA chemistry but absent in biological and synthetic ion channels and pores. Here, a novel rigid-rod pi-stack architecture is introduced to create synthetic ion channels with characteristics that are at the forefront of rational design, that is, ligand gating by a conformational change of the functional supramolecule. Namely, the intercalation of electron-rich aromatics is designed to untwist inactive electron-poor helical pi-stacks without internal space into open barrel-stave ion channels. Conductance experiments in planar lipid bilayers corroborate results from spherical bilayers and molecular modeling: Highly cooperative and highly selective ligand gating produces small, long-lived, weakly anion selective, ohmic ion channels. Structural studies conducted under conditions relevant for function provide experimental support for helix-barrel transition as origin of ligand gating. Control experiments demonstrate that minor structural changes leading to internal decrowding suffice to cleanly annihilate chiral self-organization and function.
Keywords Bioorganic chemistryIon channelsPi interactionsSelf-assemblySupramolecular chemistry
PMID: 16118825
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
TALUKDAR, Pinaki et al. Ligand-Gated Synthetic Ion Channels. In: Chemistry - A European Journal, 2005, vol. 11, n° 22, p. 6525-6532. doi: 10.1002/chem.200500516 https://archive-ouverte.unige.ch/unige:7763

415 hits



Deposited on : 2010-06-21

Export document
Format :
Citation style :