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Scientific article
English

Antifungal hydrogels

Contributors

Zumbuehl, Andréas; Ferreira, Lino; Kuhn, Duncan; Astashkina, Anna; Lon, Lisa; Yeo, Yoon; Iaconis, Tiffany; Ghannoum, Mahmoud; Fink, Gerald R.; Langer, Robert; Kohane, Daniel S.

Published in

Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 32, p. 12994-12998

Publication date

2007

Abstract

Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed. Amphogel kills fungi within 2 h of contact and can be reused for at least 53 days without losing its effectiveness against Candida albicans. The antifungal material is biocompatible in vivo and does not cause hemolysis in human blood. Amphogel inoculated with C. albicans and implanted in mice prevents fungal infection. Amphogel also mitigates fungal biofilm formation. An antifungal matrix with these properties could be used to coat a variety of medical devices such as catheters as well as industrial surfaces.

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

ZUMBUEHL, Andréas et al. Antifungal hydrogels. In: Proceedings of the National Academy of Sciences of the United States of America, 2007, vol. 104, n° 32, p. 12994–12998. doi: 10.1073/pnas.0705250104

Main files (1)

Article

Identifiers

Journal ISSN

0027-8424
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Technical informations

Creation

21/06/2010 10:27:33

First validation

21/06/2010 10:27:33

Update

14/03/2023 15:46:33

Status update

14/03/2023 15:46:33

Last indexation

29/10/2024 15:23:36
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