An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia

Fraga-Silva, Rodrigo A; Costa-Fraga, Fabiana P; Savergnini, Silvia Q; De Sousa, Frederico B; Montecucco, Fabrizio; da Silva, Daniele; Sinisterra, Ruben D; Mach, François; Stergiopulos, Nikolaos; da Silva, Rafaela F; Santos, Robson A S

doi:10.1111/jsm.12262

Scientific article

English

An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia

ContributorsFraga-Silva, Rodrigo A; Costa-Fraga, Fabiana P; Savergnini, Silvia Q; De Sousa, Frederico B; Montecucco, Fabrizio; da Silva, Daniele; Sinisterra, Ruben D; Mach, François; Stergiopulos, Nikolaos; da Silva, Rafaela F; Santos, Robson A S

Published inThe journal of sexual medicine, vol. 10, no. 10, p. 2430-2442

Publication date2013

Abstract

The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile erection by activation of receptor Mas. Recently, we have developed a formulation based on Ang-(1-7) inclusion in cyclodextrin (CyD) [Ang-(1-7)-CyD], which allows for the oral administration of Ang-(1-7).

Keywords

Administration, Oral
Angiotensin I/administration & dosage
Animals
Apolipoproteins E/deficiency/genetics
Collagen/metabolism
Cyclodextrins/administration & dosage
Disease Models, Animal
Endothelium, Vascular/drug effects/metabolism/physiopathology
Fibrosis
Hypercholesterolemia/complications/genetics/metabolism/physiopathology
Impotence, Vasculogenic/drug therapy/etiology/metabolism/physiopathology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide/blood
Nitric Oxide Synthase Type I/metabolism
Nitric Oxide Synthase Type III/metabolism
Oxidative Stress/drug effects
Penile Erection/drug effects
Penis/blood supply/drug effects/metabolism/physiopathology
Peptide Fragments/administration & dosage
Phosphoproteins/metabolism
Proto-Oncogene Proteins/metabolism
Reactive Oxygen Species/metabolism
Receptor, Angiotensin, Type 1/metabolism
Receptors, G-Protein-Coupled/metabolism
Vasodilation/drug effects
Vasodilator Agents/administration & dosage

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Athérosclérose (591)

Citation (ISO format)

FRAGA-SILVA, Rodrigo A et al. An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia. In: The journal of sexual medicine, 2013, vol. 10, n° 10, p. 2430–2442. doi: 10.1111/jsm.12262

Article (Published version)

Identifiers

PID : unige:77543
DOI : 10.1111/jsm.12262
PMID : 23890028

Journal ISSN1743-6095

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An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia

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