Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice

Lenglet, Sébastien; Thomas, Aurélien; Soehnlein, Oliver; Montecucco, Fabrizio; Burger, Fabienne; Pelli, Graziano; Galan, Katia; Cravatt, Benjamin; Staub, Christian; Steffens, Sabine

doi:10.1161/ATVBAHA.112.300275

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Title		Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice
Authors		Lenglet, Sébastien Thomas, Aurélien Soehnlein, Oliver Montecucco, Fabrizio Burger, Fabienne Pelli, Graziano Galan, Katia Cravatt, Benjamin Staub, Christian Steffens, Sabine show all authors [1 - 10]
Published in		Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, vol. 33, no. 2, p. 215-223
Abstract		Endocannabinoid levels are elevated in human and mouse atherosclerosis, but their causal role is not well understood. Therefore, we studied the involvement of fatty acid amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in atherosclerotic plaque vulnerability.
Keywords		Amidohydrolases/antagonists & inhibitors/deficiency/genetics — Animals — Aorta/drug effects/enzymology/immunology/pathology — Aortic Diseases/enzymology/genetics/immunology/pathology — Apolipoproteins E/deficiency/genetics — Arachidonic Acids/blood — Atherosclerosis/enzymology/genetics/immunology/pathology — Benzamides/pharmacology — Carbamates/pharmacology — Cells, Cultured — Chemokine CXCL1/metabolism — Cholesterol/blood — Disease Models, Animal — Endocannabinoids/blood — Enzyme Inhibitors/pharmacology — Ethanolamines/blood — Genotype — Inflammation Mediators/metabolism — Interferon-gamma/metabolism — Matrix Metalloproteinase 9/metabolism — Mice — Mice, Inbred C57BL — Mice, Knockout — Muscle, Smooth, Vascular/immunology/pathology — Neutrophil Infiltration/drug effects — Neutrophils/drug effects/immunology — Oleic Acids/blood — Palmitic Acids/blood — Phenotype — Plaque, Atherosclerotic — Polyunsaturated Alkamides/blood — Spleen/immunology — T-Lymphocytes, Regulatory/immunology — Time Factors — Tumor Necrosis Factor-alpha/metabolism
Identifiers		DOI: 10.1161/ATVBAHA.112.300275 PMID: 23241405
Full text		Article (Published version) (1.7 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		L'athérosclérose et ses complications cliniques (591)
Citation (ISO format)		LENGLET, Sébastien et al. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, vol. 33, n° 2, p. 215-223. doi: 10.1161/ATVBAHA.112.300275 https://archive-ouverte.unige.ch/unige:77539