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Title

Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice

Authors
Soehnlein, Oliver
Cravatt, Benjamin
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, vol. 33, no. 2, p. 215-223
Abstract Endocannabinoid levels are elevated in human and mouse atherosclerosis, but their causal role is not well understood. Therefore, we studied the involvement of fatty acid amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in atherosclerotic plaque vulnerability.
Keywords Amidohydrolases/antagonists & inhibitors/deficiency/geneticsAnimalsAorta/drug effects/enzymology/immunology/pathologyAortic Diseases/enzymology/genetics/immunology/pathologyApolipoproteins E/deficiency/geneticsArachidonic Acids/bloodAtherosclerosis/enzymology/genetics/immunology/pathologyBenzamides/pharmacologyCarbamates/pharmacologyCells, CulturedChemokine CXCL1/metabolismCholesterol/bloodDisease Models, AnimalEndocannabinoids/bloodEnzyme Inhibitors/pharmacologyEthanolamines/bloodGenotypeInflammation Mediators/metabolismInterferon-gamma/metabolismMatrix Metalloproteinase 9/metabolismMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, Vascular/immunology/pathologyNeutrophil Infiltration/drug effectsNeutrophils/drug effects/immunologyOleic Acids/bloodPalmitic Acids/bloodPhenotypePlaque, AtheroscleroticPolyunsaturated Alkamides/bloodSpleen/immunologyT-Lymphocytes, Regulatory/immunologyTime FactorsTumor Necrosis Factor-alpha/metabolism
Identifiers
PMID: 23241405
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Structures
Research group L'athérosclérose et ses complications cliniques (591)
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LENGLET, Sébastien et al. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, vol. 33, n° 2, p. 215-223. https://archive-ouverte.unige.ch/unige:77539

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Deposited on : 2015-11-23

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