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Scientific article
English

Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice

Published inArteriosclerosis, thrombosis, and vascular biology, vol. 33, no. 2, p. 215-223
Publication date2013
Abstract

Endocannabinoid levels are elevated in human and mouse atherosclerosis, but their causal role is not well understood. Therefore, we studied the involvement of fatty acid amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in atherosclerotic plaque vulnerability.

Keywords
  • Amidohydrolases/antagonists & inhibitors/deficiency/genetics
  • Animals
  • Aorta/drug effects/enzymology/immunology/pathology
  • Aortic Diseases/enzymology/genetics/immunology/pathology
  • Apolipoproteins E/deficiency/genetics
  • Arachidonic Acids/blood
  • Atherosclerosis/enzymology/genetics/immunology/pathology
  • Benzamides/pharmacology
  • Carbamates/pharmacology
  • Cells, Cultured
  • Chemokine CXCL1/metabolism
  • Cholesterol/blood
  • Disease Models, Animal
  • Endocannabinoids/blood
  • Enzyme Inhibitors/pharmacology
  • Ethanolamines/blood
  • Genotype
  • Inflammation Mediators/metabolism
  • Interferon-gamma/metabolism
  • Matrix Metalloproteinase 9/metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular/immunology/pathology
  • Neutrophil Infiltration/drug effects
  • Neutrophils/drug effects/immunology
  • Oleic Acids/blood
  • Palmitic Acids/blood
  • Phenotype
  • Plaque, Atherosclerotic
  • Polyunsaturated Alkamides/blood
  • Spleen/immunology
  • T-Lymphocytes, Regulatory/immunology
  • Time Factors
  • Tumor Necrosis Factor-alpha/metabolism
Citation (ISO format)
LENGLET, Sébastien et al. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 2, p. 215–223. doi: 10.1161/ATVBAHA.112.300275
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Article (Published version)
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Identifiers
ISSN of the journal1079-5642
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