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Angiotensin II receptor antagonists in acute coronary syndromes

Artom, Nathan
Dallegri, Franco
Pende, Aldo
Published in European Journal of Clinical Investigation. 2014, vol. 44, no. 2, p. 219-230
Abstract BACKGROUND:It is well known that inappropriate or exaggerated activity of the renin-angiotensin system might contribute to the development of systemic hypertension with consequent organ injury and associated increased risk of acute cardiovascular (CV) diseases. This review will discuss evidence form basic research and clinical studies, investigating the efficacy of angiotensin II receptor blockers (ARBs) in the management of acute coronary syndromes (ACS). MATERIALS AND METHODS:This narrative review is based on the material found on MEDLINE and PubMed up to June 2013. We looked for the terms 'angiotensin, AT1 receptor, ACE inhibitors' in combination with 'acute coronary syndromes, acute myocardial infarction, pathophysiology'. RESULTS:Preclinical studies showed relevant protective effects of ARBs to reduce adverse cardiac remodelling in animal models of acute cardiac ischaemia. However, although recommended in Consensus guidelines as a good alternative to angiotensin-converting enzyme inhibitors (ACEIs), clinical studies did not confirm a superior efficacy of the ARBs as compared to ACEIs. As a matter of fact for some authors, these drugs might potentially have deleterious effects increasing the CV risk. CONCLUSIONS:Emerging evidence from clinical trials suggests that the use of ARBs in ACS might be controversial, and caution should be used for their clinical use to replace ACEIs in ACS.
Keywords Acute Coronary Syndrome/drug therapyAngiotensin Receptor Antagonists/therapeutic useClinical Trials as TopicHumansPeptidyl-Dipeptidase A/biosynthesisReceptor, Angiotensin, Type 2/physiologyReceptors, G-Protein-Coupled/physiologyRisk FactorsVascular Remodeling/physiology
PMID: 24289238
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Research group L'athérosclérose et ses complications cliniques (591)
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ARTOM, Nathan et al. Angiotensin II receptor antagonists in acute coronary syndromes. In: European Journal of Clinical Investigation, 2014, vol. 44, n° 2, p. 219-230. doi: 10.1111/eci.12198 https://archive-ouverte.unige.ch/unige:77532

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Deposited on : 2015-11-23

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