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Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders

Cea, Michele
Cagnetta, Antonia
Damonte, Patrizia
Nahimana, Aimable
Ballestrero, Alberto
Del Rio, Alberto
Bruzzone, Santina
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Published in Current Topics in Medicinal Chemistry. 2013, vol. 13, no. 23, p. 2930-2938
Abstract NAD⁺ biosynthesis through nicotinamide phosphoribosyltransferase (NAMPT) holds potential as a target for the treatment of inflammatory disorders due to NAD(+)'s role in immune cell signaling and metabolism. In addition to its activity as an enzyme, NAMPT is also secreted in the extracellular space where it acts as a pro-inflammatory and proangiogenic cytokine. NAMPT inhibition with FK866 has anti-inflammatory activity in different models of immune disorders and it prevents ischemia-reperfusion-induced heart damage by dampening the production of neutrophil chemoattractants. NAMPT blockade with a neutralizing antibody has beneficial effects in an acute lung injury model. Last, but not least, the anticancer activity of NAMPT inhibitors may also reflect, at least in part, their ability to modify the cancer microenvironment through their anti-inflammatory properties. Overall, NAMPT inhibition holds potential for the treatment of inflammation-related disorders and the development of effective and safe NAMPT inhibitors remains an area of strong interest in pharmaceutical research.
Keywords AnimalsAnti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic useEnzyme Inhibitors/pharmacology/therapeutic useHumansInflammation/drug therapy/enzymology/metabolismMolecular StructureNAD/antagonists & inhibitors/biosynthesis/metabolismNicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolism
PMID: 24171767
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Research group L'athérosclérose et ses complications cliniques (591)
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MONTECUCCO, Fabrizio et al. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. In: Current Topics in Medicinal Chemistry, 2013, vol. 13, n° 23, p. 2930-2938. https://archive-ouverte.unige.ch/unige:77525

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Deposited on : 2015-11-23

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