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Update on evidence for treatment with ranolazine in stable angina

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Published in Swiss Medical Weekly. 2013, vol. 143, p. w13874
Abstract Chronic angina represents a major burden for public health systems because of its poor prognosis and its high treatment costs. Ranolazine is an emerging drug recently approved for the treatment of this disease. The main molecular mechanism underlying ranolazine-mediated beneficial effects has been identified as inhibition of the late Na+ current during the action potential, which potentially improves oxygen consumption, diastolic dysfunction and coronary blood flow. Moreover, this particular mechanism of action also confers on ranolazine a potential antiarrhythmic effect. The aim of this review is to update the evidence for ranolazine treatment in chronic angina and discuss its therapeutic perspectives based on the most recent clinical and experimental studies.
Keywords Acetanilides/therapeutic useAngina, Stable/drug therapyHumansPiperazines/therapeutic useSodium Channel Blockers/therapeutic useTreatment Outcome
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PMID: 24163124
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Research group L'athérosclérose et ses complications cliniques (591)
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CARBONE, Federico, MONTECUCCO, Fabrizio, MACH, François. Update on evidence for treatment with ranolazine in stable angina. In: Swiss Medical Weekly, 2013, vol. 143, p. w13874. https://archive-ouverte.unige.ch/unige:77523

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Deposited on : 2015-11-23

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