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The vulnerable coronary plaque: update on imaging technologies

Rosa, Gian Marco
Bauckneht, Matteo
Masoero, Giovanni
Seitun, Sara
Balbi, Manrico
Brunelli, Claudio
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Published in Thrombosis and Haemostasis. 2013, vol. 110, no. 4, p. 706-72
Abstract Several studies have been carried out on vulnerable plaque as the main culprit for ischaemic cardiac events. Historically, the most important diagnostic technique for studying coronary atherosclerotic disease was to determine the residual luminal diameter by angiographic measurement of the stenosis. However, it has become clear that vulnerable plaque rupture as well as thrombosis, rather than stenosis, triggers most acute ischaemic events and that the quantification of risk based merely on severity of the arterial stenosis is not sufficient. In the last decades, substantial progresses have been made on optimisation of techniques detecting the arterial wall morphology, plaque composition and inflammation. To date, the use of a single technique is not recommended to precisely identify the progression of the atherosclerotic process in human beings. In contrast, the integration of data that can be derived from multiple methods might improve our knowledge about plaque destabilisation. The aim of this narrative review is to update evidence on the accuracy of the currently available non-invasive and invasive imaging techniques in identifying components and morphologic characteristics associated with coronary plaque vulnerability.
Keywords AnimalsAortic Rupture/etiology/prevention & controlCoronary AngiographyCoronary Vessels/pathologyDiagnostic Imaging/methods/utilizationHumansPlaque, Atherosclerotic/complications/diagnosis
PMID: 23803753
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Research groups L'athérosclérose et ses complications cliniques (591)
Chimie et protéomique clinique (270)
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ROSA, Gian Marco et al. The vulnerable coronary plaque: update on imaging technologies. In: Thrombosis and Haemostasis, 2013, vol. 110, n° 4, p. 706-72. doi: 10.1160/TH13-02-0121 https://archive-ouverte.unige.ch/unige:77521

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Deposited on : 2015-11-23

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