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Autophagy in blood cancers: biological role and therapeutic implications

Nencioni, Alessio
Cea, Michele
Longo, Valter D
Patrone, Franco
Carella, Angelo M
Holyoake, Tessa L
Helgason, G Vignir
Published in Haematologica. 2013, vol. 98, no. 9, p. 1335-1343
Abstract Autophagy is a cell recycling process the molecular apparatus of which has been identified over the past decade. Autophagy allows cells to survive starvation and inhospitable conditions and plays a key role in numerous physiological functions, including hematopoiesis and immune responses. In hematologic malignancies, autophagy can either act as a chemo-resistance mechanism or have tumor suppressive functions, depending on the context. In addition, autophagy is involved in other important aspects of blood cancers as it promotes immune competence and anti-cancer immunity, and may even help enhance patient tolerance to standard treatments. Approaches exploiting autophagy, either to activate or inhibit it, could find broad application in hematologic malignancies and contribute to improved clinical outcomes. These aspects are discussed here together with a brief introduction to the molecular machinery of autophagy and to its role in blood cell physiology.
Keywords AnimalsAutophagy/physiologyClinical Trials as Topic/methodsHematologic Neoplasms/diagnosis/metabolism/therapyHumansSignal Transduction/physiology
PMID: 24006406
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Research group L'athérosclérose et ses complications cliniques (591)
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NENCIONI, Alessio et al. Autophagy in blood cancers: biological role and therapeutic implications. In: Haematologica, 2013, vol. 98, n° 9, p. 1335-1343. doi: 10.3324/haematol.2012.079061 https://archive-ouverte.unige.ch/unige:77518

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Deposited on : 2015-11-23

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