Scientific article
Open access

Pathophysiological role of the renin-angiotensin system on erectile dysfunction

Published inEuropean journal of clinical investigation, vol. 43, no. 9, p. 978-985
Publication date2013

BACKGROUND:The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionally, we update evidence on recent findings on the role of the Ang-(1-7) and Mas receptor on the erectile function and its therapeutic potential for treating erectile dysfunction (ED). MATERIALS AND METHODS:This narrative review is based on the material searched and obtained via MEDLINE and PubMed up to November 2012. The search terms we used are 'angiotensin, erectile dysfunction, renin, Mas receptor' in combination with 'pathophysiology, fibrosis, pathways'. RESULTS:The levels of angiotensin (Ang) II, the main component of this system, are increased in the corpus cavernosum as compared to those found in the systemic circulation. Moreover, emerging evidence indicates that an increased activity of Ang II via AT1 receptor might contribute to the development of ED, whereas the pharmacological blockage of Ang II/AT1 actions has beneficial effects on the erection. On the other hand, the heptapeptide Ang-(1-7), known as a major endogenous counter-regulator of Ang II actions, favours penile erection via the activation of Mas receptor. CONCLUSIONS:Ang-(1-7) and Mas receptor pathway might be considered as a promising therapeutic target for the treatment of ED.

  • Angiotensin I/physiology
  • Angiotensin II/physiology
  • Erectile Dysfunction/etiology
  • Humans
  • Male
  • Penile Erection/physiology
  • Peptide Fragments/physiology
  • Proto-Oncogene Proteins/physiology
  • Receptor, Angiotensin, Type 1/physiology
  • Receptors, G-Protein-Coupled/physiology
  • Renin-Angiotensin System/physiology
Citation (ISO format)
FRAGA-SILVA, Rodrigo A et al. Pathophysiological role of the renin-angiotensin system on erectile dysfunction. In: European journal of clinical investigation, 2013, vol. 43, n° 9, p. 978–985. doi: 10.1111/eci.12117
Main files (1)
Article (Published version)
ISSN of the journal0014-2972

Technical informations

Creation10/14/2015 3:54:00 PM
First validation10/14/2015 3:54:00 PM
Update time03/14/2023 11:51:43 PM
Status update03/14/2023 11:51:42 PM
Last indexation01/16/2024 7:33:46 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack