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Update on the protective molecular pathways improving pancreatic beta-cell dysfunction

Puddu, Alessandra
Sanguineti, Roberta
Dallegri, Franco
Viviani, Giorgio Luciano
Published in Mediators of Inflammation. 2013, vol. 2013, p. 750540
Abstract The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.
Keywords Calcium/metabolismDiabetes Mellitus, Type 2/drug therapy/metabolism/physiopathologyGlucagon-Like Peptide 1/therapeutic useHumansHypoglycemic Agents/therapeutic useInsulin-Secreting Cells/drug effects/metabolismMetformin/therapeutic useMicroRNAs/metabolism
PMID: 23737653
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Research group L'athérosclérose et ses complications cliniques (591)
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PUDDU, Alessandra et al. Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. In: Mediators of Inflammation, 2013, vol. 2013, p. 750540. doi: 10.1155/2013/750540 https://archive-ouverte.unige.ch/unige:77513

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Deposited on : 2015-11-23

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