Scientific article
Open access

Update on the protective molecular pathways improving pancreatic beta-cell dysfunction

Published inMediators of inflammation, vol. 2013, 750540
Publication date2013

The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.

  • Calcium/metabolism
  • Diabetes Mellitus, Type 2/drug therapy/metabolism/physiopathology
  • Glucagon-Like Peptide 1/therapeutic use
  • Humans
  • Hypoglycemic Agents/therapeutic use
  • Insulin-Secreting Cells/drug effects/metabolism
  • Metformin/therapeutic use
  • MicroRNAs/metabolism
Citation (ISO format)
PUDDU, Alessandra et al. Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. In: Mediators of inflammation, 2013, vol. 2013, p. 750540. doi: 10.1155/2013/750540
Main files (1)
Article (Published version)
ISSN of the journal0962-9351

Technical informations

Creation10/14/2015 3:59:00 PM
First validation10/14/2015 3:59:00 PM
Update time03/14/2023 11:51:40 PM
Status update03/14/2023 11:51:40 PM
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