en
Scientific article
English

Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa

Published inAngewandte Chemie. International edition in English, vol. 53, no. 47, p. 12827-12831
Publication date2014
Abstract

Multidrug-resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug-resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third-generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug-resistant bacterial pathogens.

Keywords
  • Antimicrobial Cationic Peptides/chemical synthesis/chemistry/pharmacology
  • Dendrimers/chemical synthesis/chemistry/pharmacology
  • Drug Discovery
  • Drug Resistance, Multiple, Bacterial/drug effects
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Pseudomonas aeruginosa/drug effects
  • Structure-Activity Relationship
Citation (ISO format)
STACH, Michaela et al. Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa. In: Angewandte Chemie. International edition in English, 2014, vol. 53, n° 47, p. 12827–12831. doi: 10.1002/anie.201409270
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0570-0833
425views
3downloads

Technical informations

Creation10/23/2015 11:38:00 AM
First validation10/23/2015 11:38:00 AM
Update time03/14/2023 11:51:21 PM
Status update03/14/2023 11:51:21 PM
Last indexation01/16/2024 7:32:49 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack