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Title

Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa

Authors
Stach, Michaela
Siriwardena, Thissa N
Darbre, Tamis
Published in Angewandte Chemie: International Edition in English. 2014, vol. 53, no. 47, p. 12827-12831
Abstract Multidrug-resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug-resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third-generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug-resistant bacterial pathogens.
Keywords Antimicrobial Cationic Peptides/chemical synthesis/chemistry/pharmacologyDendrimers/chemical synthesis/chemistry/pharmacologyDrug DiscoveryDrug Resistance, Multiple, Bacterial/drug effectsMicrobial Sensitivity TestsMolecular ConformationPseudomonas aeruginosa/drug effectsStructure-Activity Relationship
Identifiers
PMID: 25346278
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Article (Published version) (899 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Quorom-sensing et gènes de virulence (301)
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(ISO format)
STACH, Michaela et al. Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa. In: Angewandte Chemie: International Edition in English, 2014, vol. 53, n° 47, p. 12827-12831. https://archive-ouverte.unige.ch/unige:77473

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Deposited on : 2015-11-23

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