New developments in synthetic peroxidic drugs as artemisinin mimics

Jefford, Charles

doi:10.1016/j.drudis.2007.04.009

Scientific article

English

New developments in synthetic peroxidic drugs as artemisinin mimics

Contributors

Jefford, Charles

Published in

Drug discovery today, vol. 12, no. 11-12, p. 487-495

Publication date

2007

Abstract

The present review describes the current status of synthetic cyclic peroxides, trioxanes and trioxolanes that show significant promise as antimalarial drugs because of their artemisinin-like activity. The literature from 1996 onwards is critically surveyed to provide an update on how an age-old, persistent, debilitating and frequently deadly disease could be treated by new, affordable and effective medicines possessing the peroxide pharmacophore. The review is not exhaustive and does not cover recent progress on the lead structure artemisinin and its derivatives. Nevertheless, some mechanistic aspects gleaned from artemisinin that have relevance to synthetic peroxides are discussed.

UNIGE affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

JEFFORD, Charles. New developments in synthetic peroxidic drugs as artemisinin mimics. In: Drug discovery today, 2007, vol. 12, n° 11-12, p. 487–495. doi: 10.1016/j.drudis.2007.04.009

Article

Identifiers

PID : unige:7742
DOI : 10.1016/j.drudis.2007.04.009
PMID : 17532534

Journal ISSN

1359-6446

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New developments in synthetic peroxidic drugs as artemisinin mimics

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

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Creation

First validation

Update

Status update

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