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Title

Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed phase eluents

Authors
Villani, Claudio
Published in Chirality. 2007, vol. 19, no. 8, p. 601-606
Abstract [4]Heterohelicenium cations 1a-c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations 1a-c have been resolved by HPLC using water-based eluents containing KPF(6) as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte structure on retention and enantioselectivity was investigated.
Keywords HelicenesEnantiomersCellulose carbamateTeicoplanin aglyconCircular dichroism detection
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PMID: 17096378
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VILLANI, Claudio et al. Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed phase eluents. In: Chirality, 2007, vol. 19, n° 8, p. 601-606. https://archive-ouverte.unige.ch/unige:7741

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Deposited on : 2010-06-21

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