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Title

Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis
Authors
Gomes Quindere, Ana Luiza
Benevides, Norma Maria Barros
Carbone, Federico
Mach, François
Vuilleumier, Nicolas
Montecucco, Fabrizio
Published in Thrombosis and Haemostasis. 2014, vol. 111, no. 4, p. 634-646
Abstract Atherosclerosis is the most common pathological process underlying cardiovascular diseases. Current therapies are largely focused on alleviating hyperlipidaemia and preventing thrombotic complications, but do not completely eliminate risk of suffering recurrent acute ischaemic events. Specifically targeting the inflammatory processes may help to reduce this residual risk of major adverse cardiovascular events in atherosclerotic patients. The involvement of neutrophils in the pathophysiology of atherosclerosis is an emerging field, where evidence for their causal contribution during various stages of atherosclerosis is accumulating. Therefore, the identification of neutrophils as a potential therapeutic target may offer new therapeutic perspective to reduce the current atherosclerotic burden. This narrative review highlights the expanding role of neutrophils in atherogenesis and discusses on the potential treatment targeting neutrophil-related inflammation and associated atherosclerotic plaque vulnerability.
Keywords Animals — Antibodies, Monoclonal/therapeutic use — Atherosclerosis/immunology/therapy — Cell Adhesion Molecules/immunology — Chemokines/immunology — Clinical Trials as Topic — Drug Evaluation, Preclinical — Humans — Inflammation/immunology/therapy — Molecular Targeted Therapy — Neutrophil Infiltration/drug effects — Neutrophils/drug effects/immunology — Receptors, Chemokine/immunology — Thrombosis/immunology/therapy
Identifiers
PMID: 24285257
Full text
Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups Chimie et protéomique clinique (270)
L'athérosclérose et ses complications cliniques (591)
Citation
(ISO format) 		GOMES QUINDERE, Ana Luiza et al. Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis. In: Thrombosis and Haemostasis, 2014, vol. 111, n° 4, p. 634-646. doi: 10.1160/TH13-08-0712 https://archive-ouverte.unige.ch/unige:77404

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Deposited on : 2015-11-18

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