Scientific article

Update on the efficacy of statin treatment in acute coronary syndromes

Published inEuropean journal of clinical investigation, vol. 44, no. 5, p. 501-515
Publication date2014

The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown to promote plaque stabilization or regression in several ways, including reduction in necrotic lipid core, anti-inflammatory effects and improvement in endothelial function. The aim of this review is to summarize clinical evidence on the role of statins in secondary prevention of ACS.

  • Acute Coronary Syndrome/drug therapy/pathology
  • Epidemiologic Methods
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
  • Percutaneous Coronary Intervention
  • Plaque, Atherosclerotic/pathology
  • Time Factors
  • Treatment Outcome
Citation (ISO format)
ROSA, Gian Marco et al. Update on the efficacy of statin treatment in acute coronary syndromes. In: European journal of clinical investigation, 2014, vol. 44, n° 5, p. 501–515. doi: 10.1111/eci.12255
Main files (1)
Article (Published version)
ISSN of the journal0014-2972

Technical informations

Creation10/26/2015 10:42:00 AM
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