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Scientific Article
unige:77403 
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Update on the efficacy of statin treatment in acute coronary syndromes |
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| Authors | ||
| Published in | European Journal of Clinical Investigation. 2014, vol. 44, no. 5, p. 501-515 | |
| Abstract | The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown to promote plaque stabilization or regression in several ways, including reduction in necrotic lipid core, anti-inflammatory effects and improvement in endothelial function. The aim of this review is to summarize clinical evidence on the role of statins in secondary prevention of ACS. | |
| Keywords | Acute Coronary Syndrome/drug therapy/pathology — Epidemiologic Methods — Humans — Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use — Percutaneous Coronary Intervention — Plaque, Atherosclerotic/pathology — Time Factors — Treatment Outcome | |
| Identifiers | DOI: 10.1111/eci.12255 PMID: 24601937 | |
| Full text | ||
| Structures | ||
| Research groups | Chimie et protéomique clinique (270) L'athérosclérose et ses complications cliniques (591) | |
| Citation (ISO format) | ROSA, Gian Marco et al. Update on the efficacy of statin treatment in acute coronary syndromes. In: European Journal of Clinical Investigation, 2014, vol. 44, n° 5, p. 501-515. https://archive-ouverte.unige.ch/unige:77403 |
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