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Title

Update on the efficacy of statin treatment in acute coronary syndromes

Authors
Rosa, Gian Marco
Parodi, Antonello
Massimelli, Elena A
Brunelli, Claudio
Published in European Journal of Clinical Investigation. 2014, vol. 44, no. 5, p. 501-515
Abstract The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown to promote plaque stabilization or regression in several ways, including reduction in necrotic lipid core, anti-inflammatory effects and improvement in endothelial function. The aim of this review is to summarize clinical evidence on the role of statins in secondary prevention of ACS.
Keywords Acute Coronary Syndrome/drug therapy/pathologyEpidemiologic MethodsHumansHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic usePercutaneous Coronary InterventionPlaque, Atherosclerotic/pathologyTime FactorsTreatment Outcome
Identifiers
PMID: 24601937
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Structures
Research groups Chimie et protéomique clinique (270)
L'athérosclérose et ses complications cliniques (591)
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(ISO format)
ROSA, Gian Marco et al. Update on the efficacy of statin treatment in acute coronary syndromes. In: European Journal of Clinical Investigation, 2014, vol. 44, n° 5, p. 501-515. https://archive-ouverte.unige.ch/unige:77403

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Deposited on : 2015-11-18

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