Scientific article

Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis

Published inEuropean journal of clinical investigation, vol. 44, no. 10, p. 940-950
Publication date2014

Acute pancreatitis is characterized by inflammatory processes affecting not only the pancreas, but also the lung. Here, we investigated timing of leucocyte infiltration and chemokine expression within lung and pancreas during pancreatitis and whether treatments selectively inhibiting chemokines (using Evasins) could improve organ injury.

  • Animals
  • Anti-Inflammatory Agents/therapeutic use
  • Ceruletide/toxicity
  • Chemokine CXCL1/antagonists & inhibitors
  • Chemokine CXCL2/antagonists & inhibitors
  • Disease Models, Animal
  • Leukocytes/drug effects
  • Male
  • Mice, Inbred C57BL
  • Necrosis
  • Neutrophil Infiltration/drug effects
  • Neutrophils/drug effects
  • Oxidative Stress/drug effects
  • Pancreas/pathology
  • Pancreatitis/drug therapy
  • Reactive Oxygen Species/metabolism
  • Receptors, CXCR/therapeutic use
Citation (ISO format)
MONTECUCCO, Fabrizio et al. Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis. In: European journal of clinical investigation, 2014, vol. 44, n° 10, p. 940–950. doi: 10.1111/eci.12327
Main files (1)
Article (Published version)
ISSN of the journal0014-2972

Technical informations

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First validation11/05/2015 3:00:00 PM
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