Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis

Montecucco, Fabrizio; Mach, François; Lenglet, Sébastien; Vonlaufen, Alain; Gomes Quindere, Ana Luiza; Pelli, Graziano; Burger, Fabienne; Galan, Katia; Dallegri, Franco; Carbone, Federico; Proudfoot, Amanda E; Vuilleumier, Nicolas; Frossard, Jean-Louis

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Title		Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis
Authors		Montecucco, Fabrizio Mach, François Lenglet, Sébastien Vonlaufen, Alain Gomes Quindere, Ana Luiza Pelli, Graziano Burger, Fabienne Galan, Katia Dallegri, Franco Carbone, Federico Proudfoot, Amanda E Vuilleumier, Nicolas Frossard, Jean-Louis show all authors [1 - 13]
Published in		European Journal of Clinical Investigation. 2014, vol. 44, no. 10, p. 940-950
Abstract		Acute pancreatitis is characterized by inflammatory processes affecting not only the pancreas, but also the lung. Here, we investigated timing of leucocyte infiltration and chemokine expression within lung and pancreas during pancreatitis and whether treatments selectively inhibiting chemokines (using Evasins) could improve organ injury.
Keywords		Animals — Anti-Inflammatory Agents/therapeutic use — Ceruletide/toxicity — Chemokine CXCL1/antagonists & inhibitors — Chemokine CXCL2/antagonists & inhibitors — Disease Models, Animal — Leukocytes/drug effects — Male — Mice, Inbred C57BL — Necrosis — Neutrophil Infiltration/drug effects — Neutrophils/drug effects — Oxidative Stress/drug effects — Pancreas/pathology — Pancreatitis/drug therapy — Reactive Oxygen Species/metabolism — Receptors, CXCR/therapeutic use
Identifiers		DOI: 10.1111/eci.12327 PMID: 25132144
Full text		Article (Published version) (769 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Chimie et protéomique clinique (270) L'athérosclérose et ses complications cliniques (591)
Citation (ISO format)		MONTECUCCO, Fabrizio et al. Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis. In: European Journal of Clinical Investigation, 2014, vol. 44, n° 10, p. 940-950. https://archive-ouverte.unige.ch/unige:77372