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Title

Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis

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Published in European Journal of Clinical Investigation. 2014, vol. 44, no. 10, p. 940-950
Abstract Acute pancreatitis is characterized by inflammatory processes affecting not only the pancreas, but also the lung. Here, we investigated timing of leucocyte infiltration and chemokine expression within lung and pancreas during pancreatitis and whether treatments selectively inhibiting chemokines (using Evasins) could improve organ injury.
Keywords AnimalsAnti-Inflammatory Agents/therapeutic useCeruletide/toxicityChemokine CXCL1/antagonists & inhibitorsChemokine CXCL2/antagonists & inhibitorsDisease Models, AnimalLeukocytes/drug effectsMaleMice, Inbred C57BLNecrosisNeutrophil Infiltration/drug effectsNeutrophils/drug effectsOxidative Stress/drug effectsPancreas/pathologyPancreatitis/drug therapyReactive Oxygen Species/metabolismReceptors, CXCR/therapeutic use
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PMID: 25132144
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Research groups Chimie et protéomique clinique (270)
L'athérosclérose et ses complications cliniques (591)
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MONTECUCCO, Fabrizio et al. Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis. In: European Journal of Clinical Investigation, 2014, vol. 44, n° 10, p. 940-950. https://archive-ouverte.unige.ch/unige:77372

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Deposited on : 2015-11-18

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