Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Gramoun, Azza; Crowe, Lindsey; Maurizi, Lionel; Wirth, Wolfgang; Tobalem, Frank; Grosdemange, Kerstin; Coullerez, Geraldine; Eckstein, Felix; Koenders, Marije I; Van den Berg, Wim B; Hofmann, Heinrich; Vallée, Jean-Paul

doi:10.1186/ar4588

Scientific article

Open access

English

Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

ContributorsGramoun, Azza; Crowe, Lindsey; Maurizi, Lionel; Wirth, Wolfgang; Tobalem, Frank; Grosdemange, Kerstin; Coullerez, Geraldine; Eckstein, Felix; Koenders, Marije I; Van den Berg, Wim B; Hofmann, Heinrich; Vallée, Jean-Paul

Published inArthritis research & therapy, vol. 16, no. 3, R131

Publication date2014

Abstract

Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo superparamagnetic iron oxide nanoparticle (SPION) labeled macrophages to evaluate RA treatment by MRI.

Keywords

Animals
Anti-Inflammatory Agents/pharmacology
Antigens, CD/metabolism
Antigens, Differentiation, Myelomonocytic/metabolism
Arthritis, Experimental/drug therapy/metabolism/radiography
Contrast Media/diagnostic use
Dexamethasone/pharmacology
Dose-Response Relationship, Drug
Drug Monitoring/methods
Edema/drug therapy/metabolism/radiography
Female
Ferrocyanides/chemistry
Gadolinium DTPA/diagnostic use
Immunohistochemistry
Knee Joint/chemistry/drug effects/radiography
Macrophages/chemistry/drug effects/radiography
Magnetic Resonance Imaging/methods
Magnetite Nanoparticles/chemistry
Rats, Inbred Lew
Reproducibility of Results
Staining and Labeling/methods
Synovial Membrane/drug effects/pathology/radiography

Affiliation

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research group

Imagerie cardiaque fonctionnelle (541)

Citation (ISO format)

GRAMOUN, Azza et al. Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages. In: Arthritis research & therapy, 2014, vol. 16, n° 3, p. R131. doi: 10.1186/ar4588

Article (Published version)

CC BY

Identifiers

PID : unige:77352
DOI : 10.1186/ar4588
PMID : 24957862

ISSN of the journal1478-6354

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Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

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