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Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Maurizi, Lionel
Wirth, Wolfgang
Coullerez, Geraldine
Eckstein, Felix
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Published in Arthritis research & therapy. 2014, vol. 16, no. 3, R131
Abstract Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo superparamagnetic iron oxide nanoparticle (SPION) labeled macrophages to evaluate RA treatment by MRI.
Keywords AnimalsAnti-Inflammatory Agents/pharmacologyAntigens, CD/metabolismAntigens, Differentiation, Myelomonocytic/metabolismArthritis, Experimental/drug therapy/metabolism/radiographyContrast Media/diagnostic useDexamethasone/pharmacologyDose-Response Relationship, DrugDrug Monitoring/methodsEdema/drug therapy/metabolism/radiographyFemaleFerrocyanides/chemistryGadolinium DTPA/diagnostic useImmunohistochemistryKnee Joint/chemistry/drug effects/radiographyMacrophages/chemistry/drug effects/radiographyMagnetic Resonance Imaging/methodsMagnetite Nanoparticles/chemistryRats, Inbred LewReproducibility of ResultsStaining and Labeling/methodsSynovial Membrane/drug effects/pathology/radiography
PMID: 24957862
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GRAMOUN, Azza et al. Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages. In: Arthritis research & therapy, 2014, vol. 16, n° 3, p. R131. doi: 10.1186/ar4588 https://archive-ouverte.unige.ch/unige:77352

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Deposited on : 2015-11-18

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