Scientific article
Open access

Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Published inArthritis research & therapy, vol. 16, no. 3, R131
Publication date2014

Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo superparamagnetic iron oxide nanoparticle (SPION) labeled macrophages to evaluate RA treatment by MRI.

  • Animals
  • Anti-Inflammatory Agents/pharmacology
  • Antigens, CD/metabolism
  • Antigens, Differentiation, Myelomonocytic/metabolism
  • Arthritis, Experimental/drug therapy/metabolism/radiography
  • Contrast Media/diagnostic use
  • Dexamethasone/pharmacology
  • Dose-Response Relationship, Drug
  • Drug Monitoring/methods
  • Edema/drug therapy/metabolism/radiography
  • Female
  • Ferrocyanides/chemistry
  • Gadolinium DTPA/diagnostic use
  • Immunohistochemistry
  • Knee Joint/chemistry/drug effects/radiography
  • Macrophages/chemistry/drug effects/radiography
  • Magnetic Resonance Imaging/methods
  • Magnetite Nanoparticles/chemistry
  • Rats, Inbred Lew
  • Reproducibility of Results
  • Staining and Labeling/methods
  • Synovial Membrane/drug effects/pathology/radiography
Citation (ISO format)
GRAMOUN, Azza et al. Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages. In: Arthritis research & therapy, 2014, vol. 16, n° 3, p. R131. doi: 10.1186/ar4588
Main files (1)
Article (Published version)
ISSN of the journal1478-6354

Technical informations

Creation11/18/2015 9:26:00 AM
First validation11/18/2015 9:26:00 AM
Update time03/14/2023 11:50:09 PM
Status update03/14/2023 11:50:08 PM
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