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Correctly validating results from single molecule data: The case of stretched exponential decay in the catalytic activity of single lipase B molecules

Authors
Flomenbom, Ophir
Hofkens, Johan
de Schryver, Frans C.
Rowan, Alan E.
Nolte, Roeland J.M.
Klafter, Joseph
Silbey, Robert J.
Published in Chemical Physics Letters. 2006, vol. 432, no. 1-3, p. 371-374
Abstract The question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, off ( t )= 0 e -( t / t ) α, generates the off periods of a two-state trajectory, a reliable recovery of the input off ( t ) from the trajectory is obtained even when the bin size used to define the trajectory, d t, is much larger than the parameter t. This holds true as long as the first moment of the WT-PDF is much larger than d t. Our results validate the results in an earlier study of the activity of single lipase B molecules and disprove recent related critique.
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FLOMENBOM, Ophir et al. Correctly validating results from single molecule data: The case of stretched exponential decay in the catalytic activity of single lipase B molecules. In: Chemical Physics Letters, 2006, vol. 432, n° 1-3, p. 371-374. https://archive-ouverte.unige.ch/unige:7733

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Deposited on : 2010-06-21

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