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90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT)

Published in Clinical Nuclear Medicine. 2015, vol. 40, no. 4, p. 355-357
Abstract Biodistribution and dosimetric aspects are important issues in the preparation realization of radionuclide therapies and thus play an emerging role in radioembolization of liver malignancies. Biodistribution assessment of liver selective internal radiotherapy (SIRT) has been shown feasible using PET/CT PET/magnetic resonance (MR). Whereas prospective dosimetry using 99mTc macroaggregated albumin SPECT/CT is discussed controversially, retrospective 90Y PET/CT has been shown feasible for dosimetry of SIRT in recent studies. Considering the advantages of PET/MR with regard to lesion detection radiation dose reduction compared to PET/CT, especially when repeated scanning is intended, we investigated the use of PET/MR for dosimetry of liver SIRT.
Keywords AgedCarcinoma, Hepatocellular/radiotherapy/therapyEmbolization, TherapeuticFemaleHumansLiver Neoplasms/radiotherapy/therapyMagnetic Resonance ImagingPositron-Emission TomographyRadiopharmaceuticals/administration & dosage/pharmacokinetics/therapeutic useRadiotherapy DosageTissue DistributionYttrium Radioisotopes/administration & dosage/pharmacokinetics/therapeutic use
PMID: 25674869
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Research groups Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
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WISSMEYER, Michael et al. 90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT). In: Clinical Nuclear Medicine, 2015, vol. 40, n° 4, p. 355-357. doi: 10.1097/RLU.0000000000000713 https://archive-ouverte.unige.ch/unige:77192

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Deposited on : 2015-11-11

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