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Scientific article
English

90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT)

Contributors

Wissmeyer, Michael; Delattre, Bénédicte; Zaidi, Habib; Terraz, Sylvain; Ratib, Osman

Published in

Clinical nuclear medicine, vol. 40, no. 4, p. 355-357

Publication date

2015

Abstract

Biodistribution and dosimetric aspects are important issues in the preparation realization of radionuclide therapies and thus play an emerging role in radioembolization of liver malignancies. Biodistribution assessment of liver selective internal radiotherapy (SIRT) has been shown feasible using PET/CT PET/magnetic resonance (MR). Whereas prospective dosimetry using 99mTc macroaggregated albumin SPECT/CT is discussed controversially, retrospective 90Y PET/CT has been shown feasible for dosimetry of SIRT in recent studies. Considering the advantages of PET/MR with regard to lesion detection radiation dose reduction compared to PET/CT, especially when repeated scanning is intended, we investigated the use of PET/MR for dosimetry of liver SIRT.

Keywords

  • Aged
  • Carcinoma, Hepatocellular/radiotherapy/therapy
  • Embolization, Therapeutic
  • Female
  • Humans
  • Liver Neoplasms/radiotherapy/therapy
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography
  • Radiopharmaceuticals/administration & dosage/pharmacokinetics/therapeutic use
  • Radiotherapy Dosage
  • Tissue Distribution
  • Yttrium Radioisotopes/administration & dosage/pharmacokinetics/therapeutic use

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

WISSMEYER, Michael et al. 90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT). In: Clinical nuclear medicine, 2015, vol. 40, n° 4, p. 355–357. doi: 10.1097/RLU.0000000000000713

Identifiers

Journal ISSN

0363-9762
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Technical informations

Creation

11/11/2015 14:08:00

First validation

11/11/2015 14:08:00

Update

14/03/2023 23:49:15

Status update

14/03/2023 23:49:15

Last indexation

31/10/2024 01:53:04
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