UNIGE document Scientific Article
previous document  unige:77165  next document
add to browser collection
Title

Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing

Authors
Lyashchenko, Konstantin P
Greenwald, Rena
Esfandiari, Javan
Lecu, Alexis
Waters, W Ray
Posthaus, Horst
Bodmer, Thomas
show hidden authors show all authors [1 - 13]
Published in Veterinary Medicine International. 2012, vol. 2012, p. 642145
Abstract A case of pulmonary tuberculosis caused by Mycobacterium tuberculosis was diagnosed in a horse. Clinical evaluation performed prior to euthanasia did not suggest tuberculosis, but postmortem examination provided pathological and bacteriological evidence of mycobacteriosis. In the lungs, multiple tuberculoid granulomas communicating with the bronchiolar lumen, pleural effusion, and a granulomatous lymphadenitis involving mediastinal and tracheobronchial lymph nodes were found. Serologic response to M. tuberculosis antigens was detected in the infected horse, but not in the group of 42 potentially exposed animals (18 horses, 14 alpacas, 6 donkeys, and 4 dogs) which showed no signs of disease. Diagnosis of tuberculosis in live horses remains extremely difficult. Four of 20 animal handlers at the farm were positive for tuberculous infection upon follow-up testing by interferon-gamma release assay, indicating a possibility of interspecies transmission of M. tuberculosis.
Identifiers
PMID: 22567544
Full text
Article (Published version) (1.8 MB) - public document Free access
Structures
Research group Groupe Gasche-Soccal Paola (958)
Citation
(ISO format)
LYASHCHENKO, Konstantin P et al. Pulmonary Disease due to Mycobacterium tuberculosis in a Horse: Zoonotic Concerns and Limitations of Antemortem Testing. In: Veterinary Medicine International, 2012, vol. 2012, p. 642145. https://archive-ouverte.unige.ch/unige:77165

103 hits

40 downloads

Update

Deposited on : 2015-11-11

Export document
Format :
Citation style :