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Title

Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

Authors
Noetzli, Muriel
Eyer, Stephan
Wilhelm, Laurence
Stancu, Ioana
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Published in British Journal of Clinical Pharmacology. 2014, vol. 78, no. 1, p. 135-144
Abstract A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a naturalistic setting.
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PMID: 24433464
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Article (Published version) (879 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
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NOETZLI, Muriel et al. Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance. In: British Journal of Clinical Pharmacology, 2014, vol. 78, n° 1, p. 135-144. https://archive-ouverte.unige.ch/unige:77123

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Deposited on : 2015-11-11

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