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Title

Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial
Authors
Joyeux-Faure, Marie
Tamisier, Renaud
Baguet, Jean-Philippe
Dias-Domingos, Sonia
Perrig, Stephan
Leftheriotis, Georges
Janssens, Jean-Paul
Trzepizur, Wojciech
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Published in Mediators of Inflammation. 2014, vol. 2014, p. 423120
Abstract Accumulated evidence implicates sympathetic activation as inducing oxidative stress and systemic inflammation, which in turn lead to hypertension, endothelial dysfunction, and atherosclerosis in obstructive sleep apnea (OSA). Statins through their pleiotropic properties may modify inflammation, lipid profile, and cardiovascular outcomes in OSA.
Keywords Adult — Aged — Atherosclerosis/drug therapy — Blood Pressure/drug effects — Cholesterol, LDL/metabolism — Double-Blind Method — Female — Heptanoic Acids/therapeutic use — Humans — Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use — Male — Middle Aged — Pyrroles/therapeutic use — Sleep Apnea, Obstructive/drug therapy/metabolism
Identifiers
PMID: 25221387
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Article (Published version) (658 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group Groupe Gasche-Soccal Paola (958)
Citation
(ISO format) 		JOYEUX-FAURE, Marie et al. Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial. In: Mediators of Inflammation, 2014, vol. 2014, p. 423120. https://archive-ouverte.unige.ch/unige:77044

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Deposited on : 2015-11-09

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