Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial

Joyeux-Faure, Marie; Tamisier, Renaud; Baguet, Jean-Philippe; Dias-Domingos, Sonia; Perrig, Stephan; Leftheriotis, Georges; Janssens, Jean-Paul; Trzepizur, Wojciech; Launois, Sandrine H; Stanke-Labesque, Françoise; Lévy, Patrick A; Gagnadoux, Frédéric; Pepin, Jean-Louis

doi:10.1155/2014/423120

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial
Authors		Joyeux-Faure, Marie Tamisier, Renaud Baguet, Jean-Philippe Dias-Domingos, Sonia Perrig, Stephan Leftheriotis, Georges Janssens, Jean-Paul Trzepizur, Wojciech Launois, Sandrine H Stanke-Labesque, Françoise Lévy, Patrick A Gagnadoux, Frédéric Pepin, Jean-Louis show all authors [1 - 13]
Published in		Mediators of Inflammation. 2014, vol. 2014, p. 423120
Abstract		Accumulated evidence implicates sympathetic activation as inducing oxidative stress and systemic inflammation, which in turn lead to hypertension, endothelial dysfunction, and atherosclerosis in obstructive sleep apnea (OSA). Statins through their pleiotropic properties may modify inflammation, lipid profile, and cardiovascular outcomes in OSA.
Keywords		Adult — Aged — Atherosclerosis/drug therapy — Blood Pressure/drug effects — Cholesterol, LDL/metabolism — Double-Blind Method — Female — Heptanoic Acids/therapeutic use — Humans — Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use — Male — Middle Aged — Pyrroles/therapeutic use — Sleep Apnea, Obstructive/drug therapy/metabolism
Identifiers		DOI: 10.1155/2014/423120 PMID: 25221387
Full text		Article (Published version) (658 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Groupe Gasche-Soccal Paola (958)
Citation (ISO format)		JOYEUX-FAURE, Marie et al. Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial. In: Mediators of Inflammation, 2014, vol. 2014, p. 423120. doi: 10.1155/2014/423120 https://archive-ouverte.unige.ch/unige:77044