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Title

Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial

Authors
Joyeux-Faure, Marie
Tamisier, Renaud
Baguet, Jean-Philippe
Dias-Domingos, Sonia
Leftheriotis, Georges
Trzepizur, Wojciech
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Published in Mediators of Inflammation. 2014, vol. 2014, p. 423120
Abstract Accumulated evidence implicates sympathetic activation as inducing oxidative stress and systemic inflammation, which in turn lead to hypertension, endothelial dysfunction, and atherosclerosis in obstructive sleep apnea (OSA). Statins through their pleiotropic properties may modify inflammation, lipid profile, and cardiovascular outcomes in OSA.
Keywords AdultAgedAtherosclerosis/drug therapyBlood Pressure/drug effectsCholesterol, LDL/metabolismDouble-Blind MethodFemaleHeptanoic Acids/therapeutic useHumansHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic useMaleMiddle AgedPyrroles/therapeutic useSleep Apnea, Obstructive/drug therapy/metabolism
Identifiers
PMID: 25221387
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Article (Published version) (658 Kb) - public document Free access
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Research group Groupe Gasche-Soccal Paola (958)
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JOYEUX-FAURE, Marie et al. Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial. In: Mediators of Inflammation, 2014, vol. 2014, p. 423120. https://archive-ouverte.unige.ch/unige:77044

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Deposited on : 2015-11-09

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