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Title

Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability

Authors
Adam, Martin
Imboden, Medea
Boes, Eva
Schaffner, Emmanuel
Künzli, Nino
Phuleria, Harish Chandra
Kronenberg, Florian
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Published in PLOS ONE. 2014, vol. 9, no. 8, p. e104978
Abstract Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of polymorphisms in a major proinflammatory marker gene, interleukin 6 (IL6), on the relationship between long-term exposure to traffic-related PM10 (TPM10) and HRV.
Keywords AgedAutonomic Nervous System/drug effects/metabolismCross-Sectional StudiesElectrocardiographyFemaleGenotypeHeart Rate/drug effectsHumansInterleukin-6/geneticsMaleMiddle AgedParticulate Matter/toxicityPolymorphism, Genetic/geneticsPromoter Regions, Genetic/genetics
Identifiers
PMID: 25133672
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Article (Published version) (211 Kb) - public document Free access
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Research group Groupe Jean-Michel Gaspoz (23)
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ADAM, Martin et al. Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability. In: PLOS ONE, 2014, vol. 9, n° 8, p. e104978. https://archive-ouverte.unige.ch/unige:77025

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Deposited on : 2015-11-09

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