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Title

Comparative Efficacy of Novel DMARDs as Monotherapy and in Combination with Methotrexate in Rheumatoid Arthritis Patients with Inadequate Response to Conventional DMARDs: A Network Meta-Analysis

Authors
Buckley, Felicity
Huizinga, Tom W J
Dejonckheere, Fred
Jansen, Jeroen P
Published in Journal of Managed Care & Specialty Pharmacy. 2015, vol. 21, no. 5, p. 409-423
Abstract Given the availability of a number of alternative biologic treatment options and other novel disease-modifying antirheumatic drugs (DMARDs) for the treatment of patients with rheumatoid arthritis (RA), clinicians are faced with an increasingly challenging choice regarding optimal treatment. Biologics are usually combined with traditional DMARDs, primarily methotrexate (MTX), but some biologics and tofacitinib (together referred to in this article as novel DMARDs) have been shown to be efficacious as monotherapy as well. In real-world practice, approximately one-third of RA patients receiving biologics are on monotherapy, primarily because of intolerance of, or noncompliance with, MTX. Limited data, however, are available analyzing the effectiveness of monotherapy compared with combination therapy across novel DMARDs.
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PMID: 25943002
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Research group Mécanisme de l'inflammation articulaire (44)
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BUCKLEY, Felicity et al. Comparative Efficacy of Novel DMARDs as Monotherapy and in Combination with Methotrexate in Rheumatoid Arthritis Patients with Inadequate Response to Conventional DMARDs: A Network Meta-Analysis. In: Journal of Managed Care & Specialty Pharmacy, 2015, vol. 21, n° 5, p. 409-423. https://archive-ouverte.unige.ch/unige:76999

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Deposited on : 2015-11-09

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