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Title

Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37

Authors
Pedrigi, R M
Rochemont, Viviane
Petrova, T V
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Published in Atherosclerosis. 2015, vol. 243, no. 1, p. 1-10
Abstract Shear stress patterns influence atherogenesis and plaque stability; low laminar shear stress (LLSS) promotes unstable plaques whereas oscillatory shear stress (OSS) induces more stable plaques. Endothelial connexin37 (Cx37) expression is also regulated by shear stress, which may contribute to localization of atherosclerotic disease. Moreover, Cx37 reduces initiation of atherosclerosis by inhibiting monocyte adhesion. The present work investigates the effect of Cx37 on the phenotype of plaques induced by LLSS or OSS.
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PMID: 26342936
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Structures
Research group L'athérosclérose (665)
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PFENNIGER, Anna et al. Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37. In: Atherosclerosis, 2015, vol. 243, n° 1, p. 1-10. https://archive-ouverte.unige.ch/unige:76938

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Deposited on : 2015-11-06

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