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Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy

Wunder, D. M.
Bersinger, N. A.
Fux, C. A.
Mueller, N. J.
Cavassini, Matthias
Elzi, Luigia
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Published in Antiviral therapy. 2007, vol. 12, no. 2, p. 261-265
Abstract OBJECTIVES: To assess the prevalence of abnormal testosterone and gonadotropin values in HIV-infected men before and after 2 years of combination antiretroviral therapy (cART). DESIGN: Multicentre cohort of HIV-infected adults. METHODS: We identified 139 Caucasian antiretroviral-naive male patients who started zidovudine/ lamivudine-based cART that was virologically successful over a 2 year period. Ninety-seven were randomly chosen and plasma hormone determinations of free testosterone (fT) and luteinizing hormone (LH) at baseline and after 2 years of cART were evaluated. RESULTS: At baseline 68 patients (70%) had subnormal fT levels. In these, LH levels were low in 44%, normal in 47% and high in 9%. There was a trend for an association between lower CD4+ T-cell counts and hypogonadism. Most participants had normal FSH levels. No significant changes of fT, LH and FSH levels were observed after 2 years of cART. CONCLUSIONS: Low fT levels, mainly with normal or low LH levels and thus indicating secondary hypogonadism, are found in the majority of HIV-infected men and do not resolve during 2 years of successful cART.
Keywords AdultAnti-HIV Agents/ therapeutic useCD4 Lymphocyte CountCohort StudiesDrug Therapy, CombinationFollicle Stimulating Hormone/bloodHIV Infections/complications/ drug therapy/immunology/virologyHIV-1/ geneticsHumansHypogonadism/blood/epidemiology/ virologyLamivudine/therapeutic useLuteinizing Hormone/bloodMalePrevalenceRNA, Viral/ bloodReverse Transcriptase Inhibitors/ therapeutic useSwitzerland/epidemiologyTestosterone/bloodTime FactorsTreatment OutcomeViral LoadZidovudine/therapeutic use
PMID: 17503668
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WUNDER, D. M. et al. Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. In: Antiviral therapy, 2007, vol. 12, n° 2, p. 261-265. https://archive-ouverte.unige.ch/unige:7693

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Deposited on : 2010-06-21

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