Scientific article

Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy

Published inAntiviral therapy, vol. 12, no. 2, p. 261-265
Publication date2007

OBJECTIVES: To assess the prevalence of abnormal testosterone and gonadotropin values in HIV-infected men before and after 2 years of combination antiretroviral therapy (cART). DESIGN: Multicentre cohort of HIV-infected adults. METHODS: We identified 139 Caucasian antiretroviral-naive male patients who started zidovudine/ lamivudine-based cART that was virologically successful over a 2 year period. Ninety-seven were randomly chosen and plasma hormone determinations of free testosterone (fT) and luteinizing hormone (LH) at baseline and after 2 years of cART were evaluated. RESULTS: At baseline 68 patients (70%) had subnormal fT levels. In these, LH levels were low in 44%, normal in 47% and high in 9%. There was a trend for an association between lower CD4+ T-cell counts and hypogonadism. Most participants had normal FSH levels. No significant changes of fT, LH and FSH levels were observed after 2 years of cART. CONCLUSIONS: Low fT levels, mainly with normal or low LH levels and thus indicating secondary hypogonadism, are found in the majority of HIV-infected men and do not resolve during 2 years of successful cART.

  • Adult
  • Anti-HIV Agents/ therapeutic use
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Drug Therapy, Combination
  • Follicle Stimulating Hormone/blood
  • HIV Infections/complications/ drug therapy/immunology/virology
  • HIV-1/ genetics
  • Humans
  • Hypogonadism/blood/epidemiology/ virology
  • Lamivudine/therapeutic use
  • Luteinizing Hormone/blood
  • Male
  • Prevalence
  • RNA, Viral/ blood
  • Reverse Transcriptase Inhibitors/ therapeutic use
  • Switzerland/epidemiology
  • Testosterone/blood
  • Time Factors
  • Treatment Outcome
  • Viral Load
  • Zidovudine/therapeutic use
Citation (ISO format)
WUNDER, D. M. et al. Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. In: Antiviral therapy, 2007, vol. 12, n° 2, p. 261–265.
Updates (1)
ISSN of the journal1359-6535

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