UNIGE document Scientific Article
previous document  unige:76814  next document
add to browser collection
Title

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

Authors
Kasraee, Behrooz
Nikolic, Damjan S.
Salomon, Denis
Carraux, Pierre
Piguet, Vincent
Omrani, Gholamhossein R.
show hidden authors show all authors [1 - 9]
Published in Experimental Dermatology. 2012, vol. 21, no. 1, p. 19-24
Abstract We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 mum ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes, a pretreatment of melanocytes with ebselen resulted in a strong inhibition of melanosome transfer to keratinocytes, as shown under optical and electron microscopy. In reconstructed epidermis, topical 0.5% ebselen led to a twofold decrease of melanin without affecting the density of active melanocytes. A similar result was obtained with topical 0.5% ebselen in black guinea pig ears. Ebselen induced a decrease of epidermal melanin parallel to a localisation of melanin and melanosomes in the basal layer. Ebselen appears as a new depigmenting compound that inhibits melanin synthesis and melanosome transfer to keratinocytes.
Keywords EbselenHydrogen peroxideKeratinocytesMelanocytesPigmentation
Identifiers
PMID: 22082249
Full text
Structures
Research group La recherche en biochimie dermatologique (652)
Citation
(ISO format)
KASRAEE, Behrooz et al. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. In: Experimental Dermatology, 2012, vol. 21, n° 1, p. 19-24. https://archive-ouverte.unige.ch/unige:76814

107 hits

1 download

Update

Deposited on : 2015-11-04

Export document
Format :
Citation style :