en
Scientific article
French

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

Published inExperimental dermatology, vol. 21, no. 1, p. 19-24
Publication date2012
Abstract

We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 mum ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes, a pretreatment of melanocytes with ebselen resulted in a strong inhibition of melanosome transfer to keratinocytes, as shown under optical and electron microscopy. In reconstructed epidermis, topical 0.5% ebselen led to a twofold decrease of melanin without affecting the density of active melanocytes. A similar result was obtained with topical 0.5% ebselen in black guinea pig ears. Ebselen induced a decrease of epidermal melanin parallel to a localisation of melanin and melanosomes in the basal layer. Ebselen appears as a new depigmenting compound that inhibits melanin synthesis and melanosome transfer to keratinocytes.

Keywords
  • Ebselen
  • Hydrogen peroxide
  • Keratinocytes
  • Melanocytes
  • Pigmentation
Citation (ISO format)
KASRAEE, Behrooz et al. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. In: Experimental dermatology, 2012, vol. 21, n° 1, p. 19–24. doi: 10.1111/j.1600-0625.2011.01394.x
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Article (Published version)
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Identifiers
ISSN of the journal0906-6705
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