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Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

Kasraee, Behrooz
Nikolic, Damjan S.
Salomon, Denis
Carraux, Pierre
Piguet, Vincent
Omrani, Gholamhossein R.
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Published in Experimental dermatology. 2012, vol. 21, no. 1, p. 19-24
Abstract We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 mum ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes, a pretreatment of melanocytes with ebselen resulted in a strong inhibition of melanosome transfer to keratinocytes, as shown under optical and electron microscopy. In reconstructed epidermis, topical 0.5% ebselen led to a twofold decrease of melanin without affecting the density of active melanocytes. A similar result was obtained with topical 0.5% ebselen in black guinea pig ears. Ebselen induced a decrease of epidermal melanin parallel to a localisation of melanin and melanosomes in the basal layer. Ebselen appears as a new depigmenting compound that inhibits melanin synthesis and melanosome transfer to keratinocytes.
Keywords EbselenHydrogen peroxideKeratinocytesMelanocytesPigmentation
PMID: 22082249
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Research group La recherche en biochimie dermatologique (652)
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KASRAEE, Behrooz et al. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. In: Experimental dermatology, 2012, vol. 21, n° 1, p. 19-24. doi: 10.1111/j.1600-0625.2011.01394.x https://archive-ouverte.unige.ch/unige:76814

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Deposited on : 2015-11-04

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