Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

Kasraee, Behrooz; Nikolic, Damjan S.; Salomon, Denis; Carraux, Pierre; Fontao, Lionel; Piguet, Vincent; Omrani, Gholamhossein R.; Sorg, Olivier; Saurat, Jean-Hilaire

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Title		Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer
Authors		Kasraee, Behrooz Nikolic, Damjan S. Salomon, Denis Carraux, Pierre Fontao, Lionel Piguet, Vincent Omrani, Gholamhossein R. Sorg, Olivier Saurat, Jean-Hilaire show all authors [1 - 9]
Published in		Experimental Dermatology. 2012, vol. 21, no. 1, p. 19-24
Abstract		We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 mum ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes, a pretreatment of melanocytes with ebselen resulted in a strong inhibition of melanosome transfer to keratinocytes, as shown under optical and electron microscopy. In reconstructed epidermis, topical 0.5% ebselen led to a twofold decrease of melanin without affecting the density of active melanocytes. A similar result was obtained with topical 0.5% ebselen in black guinea pig ears. Ebselen induced a decrease of epidermal melanin parallel to a localisation of melanin and melanosomes in the basal layer. Ebselen appears as a new depigmenting compound that inhibits melanin synthesis and melanosome transfer to keratinocytes.
Keywords		Ebselen — Hydrogen peroxide — Keratinocytes — Melanocytes — Pigmentation
Identifiers		DOI: 10.1111/j.1600-0625.2011.01394.x PMID: 22082249
Full text		Article (Published version) (451 Kb) - Limited access to UNIGE Other version: http://doi.wiley.com/10.1111/j.1600-0625.2011.01394.x
Structures		Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group		La recherche en biochimie dermatologique (652)
Citation (ISO format)		KASRAEE, Behrooz et al. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. In: Experimental Dermatology, 2012, vol. 21, n° 1, p. 19-24. https://archive-ouverte.unige.ch/unige:76814