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Title

The Combination of a Retinoid, a Phenolic Agent and an Antioxidant Improves Tolerance while Retaining an Optimal Depigmenting Action in Reconstructed Epidermis

Authors
Kasraee, B.
Salomon, D.
Published in Dermatology. 2013, vol. 227, no. 2, p. 150-156
Abstract BACKGROUND: Cutaneous pigmented lesions urge the need to find safe and effective treatments to lighten the skin. OBJECTIVE: The aim of this study was to combine a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a proreducing agent (delta-tocopheryl-beta-D-glucopyranoside) to achieve synergistic actions for skin lightening. METHODS: The tolerance profile and the depigmenting properties of these agents were assessed in murine keratinocyte and melanocyte cell lines, as well as in a 3-dimensional model of reconstructed epidermis. RESULTS: Retinaldehyde and 4-(1-phenylethyl)-resorcinol induced a significant decrease of tissue viability in reconstructed epidermis, but this cytotoxicity was prevented by the addition of delta-tocopheryl-beta-D-glucopyranoside. The combination of the three agents was, however, efficient in decreasing the specific melanin content and the density of active melanocytes. CONCLUSION: A combination of various chemicals acting via different mechanisms allows a decrease in the toxicity of each compound alone while retaining optimal skin-lightening properties.
Keywords SkinRetinaldehydeTocopherolResorcinolDepigmentation
Identifiers
PMID: 24009015
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Article (Published version) (216 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.karger.com?doi=10.1159/000353578
Structures
Research group La recherche en biochimie dermatologique (652)
Citation
(ISO format)
SORG, Olivier et al. The Combination of a Retinoid, a Phenolic Agent and an Antioxidant Improves Tolerance while Retaining an Optimal Depigmenting Action in Reconstructed Epidermis. In: Dermatology, 2013, vol. 227, n° 2, p. 150-156. https://archive-ouverte.unige.ch/unige:76811

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Deposited on : 2015-11-04

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