Scientific article

Perioperative antibiotic prophylaxis of wound and foreign body infections: microbial factors affecting efficacy

Published inReviews of infectious diseases, vol. 13, no. Suppl 10, p. S782-789
Publication date1991

Numerous microbial factors are responsible for perioperative infections and influence the efficacy of antibiotic prophylaxis. These factors include the staphylococcal carrier state, bacterial adherence to a number of host proteins, the production of glycocalyx by sessile bacteria, and shifts in antibiotic resistance. A full understanding of the mechanisms involved will lead to further reductions in the number of postoperative infections. Unfortunately, the microbial factors affecting prophylaxis cannot be evaluated separately under clinical conditions; they are easier to study under circumstances whose bacteriologic features are well defined and in which the presence of foreign materials (e.g., sutures) greatly potentiates pathogenic mechanisms. Such circumstances exist, for example, in infections developing after "clean" surgery and in experimental models. Since even clean wounds are found to be contaminated when sampled carefully, the control of infection is more a quantitative than a qualitative problem. The critical period for the development of infection is short: an antibiotic course not exceeding 24 hours seems effective in preventing infection.

  • Animals
  • Anti-Bacterial Agents/ therapeutic use
  • Bacterial Adhesion
  • Carrier State/microbiology
  • Drug Resistance, Microbial
  • Foreign Bodies/ complications
  • Humans
  • Premedication
  • Staphylococcal Infections/microbiology/prevention & control
  • Surgical Wound Infection/ prevention & control
Citation (ISO format)
WALDVOGEL, Francis et al. Perioperative antibiotic prophylaxis of wound and foreign body infections: microbial factors affecting efficacy. In: Reviews of infectious diseases, 1991, vol. 13, n° Suppl 10, p. S782–789. doi: 10.1093/clinids/13.supplement_10.s782
Updates (1)
ISSN of the journal0162-0886

Technical informations

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