Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis

Lanthier, Nicolas; Rubbia-Brandt, Laura; Lin-Marq, Nathalie; Clement, Sophie; Frossard, Jean-Louis; Goossens, Nicolas; Hadengue, Antoine; Spahr, Laurent François Joséph

doi:10.1016/j.jhep.2015.04.003

Scientific article

English

Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis

ContributorsLanthier, Nicolas; Rubbia-Brandt, Laura; Lin-Marq, Nathalie; Clement, Sophie; Frossard, Jean-Louis; Goossens, Nicolas; Hadengue, Antoine; Spahr, Laurent François Joséph

Published inJournal of hepatology, vol. 63, no. 3, p. 609-621

Publication date2015

Abstract

The role of liver progenitor cell (LPC) expansion, known as a marker of disease severity, as well as the impact of macrophage activation on liver regeneration remains unclear in humans. We aimed to characterize the LPC and macrophage compartments in alcoholic hepatitis (AH), as well as gene expression patterns to identify predictors of a good prognosis in this setting.

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Citation (ISO format)

LANTHIER, Nicolas et al. Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis. In: Journal of hepatology, 2015, vol. 63, n° 3, p. 609–621. doi: 10.1016/j.jhep.2015.04.003

Article (Accepted version)

Identifiers

PID : unige:76736
DOI : 10.1016/j.jhep.2015.04.003
PMID : 25872168

Journal ISSN0168-8278

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Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis

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