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Title

Clinical features and management of a severe paradoxical reaction associated with combined treatment of Buruli ulcer and HIV co-infection

Authors
Wanda, Franck
Nkemenang, Patrick
Ehounou, Genevieve
Tchaton, Marie
Masouyé, Isabelle
Christinet, Vanessa
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Published in BMC Infectious Diseases. 2014, vol. 14, p. 423
Abstract In West and Central Africa Buruli ulcer (BU) and HIV co-infection is increasingly recognised and management of these two diseases combined is an emerging challenge for which there is little published information. In this case we present a severe paradoxical reaction occurring after commencing antibiotic treatment for BU combined with antiretroviral therapy for HIV, and describe its clinical features and management. This includes to our knowledge the first reported use of prednisolone in Africa to manage a severe paradoxical reaction related to BU treatment.
Keywords AdultAfricaAnti-Bacterial Agents/administration & dosage/contraindicationsAnti-HIV Agents/administration & dosage/contraindicationsBuruli Ulcer/drug therapy/microbiologyCoinfection/drug therapy/microbiology/virologyHIV Infections/drug therapy/virologyHIV-1/drug effects/physiologyHumansMaleMycobacterium ulcerans/drug effects/physiology
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PMID: 25073531
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WANDA, Franck et al. Clinical features and management of a severe paradoxical reaction associated with combined treatment of Buruli ulcer and HIV co-infection. In: BMC Infectious Diseases, 2014, vol. 14, p. 423. https://archive-ouverte.unige.ch/unige:76735

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Deposited on : 2015-11-02

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