en
Scientific article
English

Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus

Published inThe Journal of infectious diseases, vol. 150, no. 4, p. 546-553
Publication date1984
Abstract

Foreign bodies made of polymethylmethacrylate coverslips were implanted subcutaneously into guinea pigs, were explanted four weeks later, and were tested for in vitro adherence of Staphylococcus aureus strain Wood 46. In the presence of serum, the level of staphylococcal adherence to explanted coverslips was 20 times higher than that of adherence to unimplanted coverslips. Adherence to explanted coverslips was caused by fibronectin deposits on the foreign body surface and was inhibited in a dose-related fashion by specific antibodies to fibronectin.

Keywords
  • Adhesiveness
  • Animals
  • Bacterial Infections/ etiology
  • Blood Proteins/pharmacology
  • Dose-Response Relationship, Drug
  • Fibronectins/immunology/ physiology
  • Foreign Bodies/complications/ microbiology
  • Guinea Pigs
  • Humans
  • Immunoglobulin G/immunology
  • Ligands
  • Methylmethacrylates
  • Prostheses and Implants/adverse effects
  • Rabbits
  • Staphylococcus aureus/ physiology
Citation (ISO format)
VAUDAUX, Pierre et al. Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus. In: The Journal of infectious diseases, 1984, vol. 150, n° 4, p. 546–553.
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0022-1899
504views
0downloads

Technical informations

Creation06/21/2010 10:26:56 AM
First validation06/21/2010 10:26:56 AM
Update time03/14/2023 3:46:02 PM
Status update03/14/2023 3:46:02 PM
Last indexation02/12/2024 6:39:15 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack