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Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus

Suzuki, R.
Morgenthaler, J. J.
Published in The journal of infectious diseases. 1984, vol. 150, no. 4, p. 546-553
Abstract Foreign bodies made of polymethylmethacrylate coverslips were implanted subcutaneously into guinea pigs, were explanted four weeks later, and were tested for in vitro adherence of Staphylococcus aureus strain Wood 46. In the presence of serum, the level of staphylococcal adherence to explanted coverslips was 20 times higher than that of adherence to unimplanted coverslips. Adherence to explanted coverslips was caused by fibronectin deposits on the foreign body surface and was inhibited in a dose-related fashion by specific antibodies to fibronectin.
Keywords AdhesivenessAnimalsBacterial Infections/ etiologyBlood Proteins/pharmacologyDose-Response Relationship, DrugFibronectins/immunology/ physiologyForeign Bodies/complications/ microbiologyGuinea PigsHumansImmunoglobulin G/immunologyLigandsMethylmethacrylatesProstheses and Implants/adverse effectsRabbitsStaphylococcus aureus/ physiology
PMID: 6491367
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Other version: http://www.jstor.org/stable/pdfplus/30131577.pdf
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VAUDAUX, Pierre et al. Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus. In: The Journal of infectious diseases, 1984, vol. 150, n° 4, p. 546-553. https://archive-ouverte.unige.ch/unige:7661

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Deposited on : 2010-06-21

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