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Title

Host factors selectively increase staphylococcal adherence on inserted catheters: a role for fibronectin and fibrinogen or fibrin

Authors
Haeberli, A.
Huggler, E.
Published in The Journal of infectious diseases. 1989, vol. 160, no. 5, p. 865-875
Abstract Intravascular catheters are prone to staphylococcal infections. To study the role in staphylococcal adherence played by fibrinogen or fibrin and fibronectin deposited on inserted catheters, 187 peripheral or central cannulae were prospectively removed from hospitalized patients. Compared with uninserted catheters, which allowed only minimal adherence, previously inserted catheters promoted significant adherence of staphylococcal isolates from patients with intravenous device infection. Adhesion-promoting properties were studied with laboratory strains having well-defined affinities for either fibronectin or fibrinogen: adherence of Staphylococcus aureus Cowan I, which has the highest affinity for both adhesins, was more strongly promoted (10- to 50-fold) on inserted cannulae than was that of S. aureus Wood 46 (4- to 10-fold) or Staphylococcus epidermidis Rp 12 (2.2-fold), which has no affinity for fibrinogen but does for fibronectin. Although all types of cannulae contained significant amounts of fibrin, which may promote adherence of coagulase-positive staphylococci, results obtained with coagulase-negative isolates suggested that in vivo-deposited fibronectin is also a critical determinant in this process.
Keywords Bacterial AdhesionCatheters, IndwellingFibrin/ physiologyFibrinogen/ physiologyFibronectins/ physiologyHumansStaphylococcal Infections/ physiopathologyStaphylococcus/ pathogenicity
Identifiers
PMID: 2809259
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Structures
Research group Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
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(ISO format)
VAUDAUX, Pierre et al. Host factors selectively increase staphylococcal adherence on inserted catheters: a role for fibronectin and fibrinogen or fibrin. In: The Journal of infectious diseases, 1989, vol. 160, n° 5, p. 865-875. doi: 10.1093/infdis/160.5.865 https://archive-ouverte.unige.ch/unige:7658

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Deposited on : 2010-06-21

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