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Scientific Article
unige:7657 
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Tolerance of staphylococci to bactericidal antibiotics |
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| Authors | ||
| Published in | Injury. 2006, vol. 37, no. Suppl 2, p. S15-19 | |
| Abstract | Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in clinical conditions or experimental trials of implant-related infections. However, the efficacy of all anti-staphylococcal agents is seriously diminished on already established implant-related deep-seated infections, which then frequently require surgical implant removal to obtain a cure. The failure of antibiotic therapy to cure established staphylococcal foreign-body infections may arise in part from a broad-spectrum phenotypic tolerance expressed in vivo to different classes of antimicrobial agents. The molecular and physiological mechanisms of this in vivo tolerance remain poorly understood. | |
| Keywords | Animals — Anti-Bacterial Agents/ therapeutic use — Disease Models, Animal — Drug Resistance, Bacterial — Guinea Pigs — Humans — Orthopedic Procedures/adverse effects — Prostheses and Implants/adverse effects — Prosthesis-Related Infections/drug therapy — Rats — Staphylococcal Infections/drug therapy/ microbiology — Staphylococcus/ drug effects/pathogenicity — Virulence | |
| Identifiers | PMID: 16651066 | |
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| Structures | ||
| Citation (ISO format) | VAUDAUX, Pierre, LEW, Daniel Pablo. Tolerance of staphylococci to bactericidal antibiotics. In: Injury, 2006, vol. 37, n° Suppl 2, p. S15-19. doi: 10.1016/j.injury.2006.04.004 https://archive-ouverte.unige.ch/unige:7657 |
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