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Tolerance of staphylococci to bactericidal antibiotics

Published in Injury. 2006, vol. 37, no. Suppl 2, p. S15-19
Abstract Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in clinical conditions or experimental trials of implant-related infections. However, the efficacy of all anti-staphylococcal agents is seriously diminished on already established implant-related deep-seated infections, which then frequently require surgical implant removal to obtain a cure. The failure of antibiotic therapy to cure established staphylococcal foreign-body infections may arise in part from a broad-spectrum phenotypic tolerance expressed in vivo to different classes of antimicrobial agents. The molecular and physiological mechanisms of this in vivo tolerance remain poorly understood.
Keywords AnimalsAnti-Bacterial Agents/ therapeutic useDisease Models, AnimalDrug Resistance, BacterialGuinea PigsHumansOrthopedic Procedures/adverse effectsProstheses and Implants/adverse effectsProsthesis-Related Infections/drug therapyRatsStaphylococcal Infections/drug therapy/ microbiologyStaphylococcus/ drug effects/pathogenicityVirulence
PMID: 16651066
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VAUDAUX, Pierre, LEW, Daniel Pablo. Tolerance of staphylococci to bactericidal antibiotics. In: Injury, 2006, vol. 37, n° Suppl 2, p. S15-19. doi: 10.1016/j.injury.2006.04.004 https://archive-ouverte.unige.ch/unige:7657

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Deposited on : 2010-06-21

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