Article - Limited access to UNIGE
Other version: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7H-4X66CDG-5-5&_cdi=5059&_user=779890&_pii=S09248579090037...
Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital
|Published in||International Journal of Antimicrobial Agents. 2009, vol. 34, no. 6, p. 540-543|
|Abstract||In this study, we assessed by broth microdilution the in vitro activity of oritavancin, a semisynthetic lipoglycopeptide currently under development, against selected meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates (n=56) from Geneva University Hospital, Switzerland, displaying a wide range of vancomycin minimum inhibitory concentrations (MICs) (0.25-4 microg/mL). The MRSA resistance phenotype was confirmed by broth microdilution (oxacillin MIC > or = 4 microg/mL) for all isolates; 89% and 100% of the tested isolates were also resistant to erythromycin and ciprofloxacin, respectively. For 53 MRSA isolates for which vancomycin MICs were in the susceptible range (0.5-2.0 microg/mL), the oritavancin MICs ranged from 0.03 microg/mL to 0.5 microg/mL. For these 53 vancomycin-susceptible isolates, the cumulative distribution of oritavancin MICs was markedly different from those of vancomycin, teicoplanin, daptomycin and linezolid MICs, yielding an oritavancin MIC for 90% of the organisms (MIC(90)) (0.25 microg/mL) that was four times lower than the MIC(90) values (1 microg/mL) of comparators. For three MRSA isolates with a vancomycin-intermediate phenotype (vancomycin MIC=4 microg/mL), oritavancin MICs (0.5-1.0 microg/mL) were 2-4-fold lower than vancomycin, teicoplanin or daptomycin MICs, but were equivalent to linezolid MICs. Pairwise comparison for each bloodstream isolate showed that oritavancin was > or =4-fold more active than vancomycin, teicoplanin and daptomycin, against 86%, 75% and 59% of all MRSA isolates, respectively.|
|Keywords||Anti-Bacterial Agents/ pharmacology — Bacteremia/ microbiology — Ciprofloxacin/pharmacology — Erythromycin/pharmacology — Glycopeptides/ pharmacology — Hospitals, Teaching — Humans — Methicillin-Resistant Staphylococcus aureus/ drug effects/isolation & — Purification — Microbial Sensitivity Tests — Staphylococcal Infections/ microbiology — Switzerland — Vancomycin/pharmacology|
|VAUDAUX, Pierre et al. Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital. In: International Journal of Antimicrobial Agents, 2009, vol. 34, n° 6, p. 540-543. https://archive-ouverte.unige.ch/unige:7654|