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Title

Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital

Authors
Huggler, Elzbieta
Arhin, F. F.
Moeck, Gregory
Published in International Journal of Antimicrobial Agents. 2009, vol. 34, no. 6, p. 540-543
Abstract In this study, we assessed by broth microdilution the in vitro activity of oritavancin, a semisynthetic lipoglycopeptide currently under development, against selected meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates (n=56) from Geneva University Hospital, Switzerland, displaying a wide range of vancomycin minimum inhibitory concentrations (MICs) (0.25-4 microg/mL). The MRSA resistance phenotype was confirmed by broth microdilution (oxacillin MIC > or = 4 microg/mL) for all isolates; 89% and 100% of the tested isolates were also resistant to erythromycin and ciprofloxacin, respectively. For 53 MRSA isolates for which vancomycin MICs were in the susceptible range (0.5-2.0 microg/mL), the oritavancin MICs ranged from 0.03 microg/mL to 0.5 microg/mL. For these 53 vancomycin-susceptible isolates, the cumulative distribution of oritavancin MICs was markedly different from those of vancomycin, teicoplanin, daptomycin and linezolid MICs, yielding an oritavancin MIC for 90% of the organisms (MIC(90)) (0.25 microg/mL) that was four times lower than the MIC(90) values (1 microg/mL) of comparators. For three MRSA isolates with a vancomycin-intermediate phenotype (vancomycin MIC=4 microg/mL), oritavancin MICs (0.5-1.0 microg/mL) were 2-4-fold lower than vancomycin, teicoplanin or daptomycin MICs, but were equivalent to linezolid MICs. Pairwise comparison for each bloodstream isolate showed that oritavancin was > or =4-fold more active than vancomycin, teicoplanin and daptomycin, against 86%, 75% and 59% of all MRSA isolates, respectively.
Keywords Anti-Bacterial Agents/ pharmacologyBacteremia/ microbiologyCiprofloxacin/pharmacologyErythromycin/pharmacologyGlycopeptides/ pharmacologyHospitals, TeachingHumansMethicillin-Resistant Staphylococcus aureus/ drug effects/isolation &PurificationMicrobial Sensitivity TestsStaphylococcal Infections/ microbiologySwitzerlandVancomycin/pharmacology
Identifiers
PMID: 19744838
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VAUDAUX, Pierre et al. Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital. In: International Journal of Antimicrobial Agents, 2009, vol. 34, n° 6, p. 540-543. https://archive-ouverte.unige.ch/unige:7654

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Deposited on : 2010-06-21

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