In modern corporations, the corporate headquarters (CHQ) unit is considered central to the fortunes of the overall firm. In light of ever-changing environments, changes at the CHQ have become a crucial concern in management research and practice, and scholars have studied a variety of changes at the CHQ. Despite the common focus on the CHQ entity and the potential for cross-fertilization across several research tracks, a coherent picture of this dispersed body of knowledge is lacking. This paper reviews 25 years of research on changes at the CHQ. In so doing, it advances a common language and an overarching framework that integrates the existing knowledge in the intellectual domains of strategy, organizational design and international business research. On this basis, the authors suggest directions for future research to advance knowledge of: (1) the pressure for and resistance to changes at the CHQ; (2) interrelationships among changes at the CHQ; (3) change processes at the CHQ; (4) agents involved in changes at the CHQ; and (5) adaptive and disruptive effects of changes at the CHQ. Overall, the study provides a conceptual basis for combining the existing knowledge of changes at the CHQ and serves as a guide for future research.