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Scientific article
English

Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus

Published inAntimicrobial agents and chemotherapy, vol. 53, no. 7, p. 3150-3152
Publication date2009
Abstract

Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 microg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.

Keywords
  • Animals
  • Anti-Bacterial Agents/ therapeutic use
  • Foreign Bodies/ drug therapy/ microbiology
  • Methicillin-Resistant Staphylococcus aureus/ physiology
  • Minocycline/ analogs & derivatives/therapeutic use
  • Rats
  • Staphylococcal Infections/ drug therapy/ microbiology
  • Vancomycin/ therapeutic use
Citation (ISO format)
VAUDAUX, Pierre et al. Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus. In: Antimicrobial agents and chemotherapy, 2009, vol. 53, n° 7, p. 3150–3152. doi: 10.1128/AAC.01612-08
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ISSN of the journal0066-4804
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