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Title

Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus

Authors
Fleury, Bénédicte
Gjinovci, Asllan
Huggler, Elzbieta
Tangomo-Bento, Manuela
Published in Antimicrobial Agents and Chemotherapy. 2009, vol. 53, no. 7, p. 3150-3152
Abstract Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 microg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.
Keywords AnimalsAnti-Bacterial Agents/ therapeutic useForeign Bodies/ drug therapy/ microbiologyMethicillin-Resistant Staphylococcus aureus/ physiologyMinocycline/ analogs & derivatives/therapeutic useRatsStaphylococcal Infections/ drug therapy/ microbiologyVancomycin/ therapeutic use
Identifiers
PMID: 19364855
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VAUDAUX, Pierre et al. Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy, 2009, vol. 53, n° 7, p. 3150-3152. https://archive-ouverte.unige.ch/unige:7647

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Deposited on : 2010-06-21

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