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Phenotypic antibiotic tolerance of Staphylococcus aureus in implant-related infections: relationship with in vitro colonization of artificial surfaces

ContributorsVaudaux, Pierre
Published inDrug resistance updates, vol. 1, no. 6, p. 352-357
Publication date1998
Abstract

Antibiotic therapy of deep-seated staphylococcal infections, especially when they are associated with foreign implants, such as orthopedic prostheses and permanently inserted catheters, is a difficult challenge. Semi-synthetic penicillins, glycopeptides and quinolones are found effective when given prophylactically in clinical and experimental trials of implant-related infections, but are frequently poorly effective after implant-related infections are established. Thus, removal of the medical devices is often required to obtain cure. The failure of antibiotic therapy to cure staphylococcal foreign body infections may arise from a broad-spectrum phenotypic tolerance to different classes of antimicrobial agents, whose molecular basis and physiological mechanisms are poorly understood.

Citation (ISO format)
VAUDAUX, Pierre. Phenotypic antibiotic tolerance of Staphylococcus aureus in implant-related infections: relationship with in vitro colonization of artificial surfaces. In: Drug resistance updates, 1998, vol. 1, n° 6, p. 352–357. doi: 10.1016/s1368-7646(98)80011-3
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ISSN of the journal1368-7646
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