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Title

Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study

Authors
Hatz, Christoph F R
Bally, Bettina
Rohrer, Susanne
Steffen, Robert
Kramme, Stefanie
Wacker, Michael
Alaimo, Cristina
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Published in Vaccine. 2015, vol. 33, no. 36, p. 4594-4601
Abstract Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protection, the safety concerns, or manufacturing challenges hindered successful market approval. Conjugated vaccines have been shown to be safe and effective for different pathogens (i.e., Neisseria meningitidis, Shigella pneumonia, Haemophilus influenzae). The bio-conjugation technology, exploited here for the Shigella dysenteriae candidate vaccine, offers a novel and potentially simpler way to develop and produce vaccines against one of the major causes of morbidity and mortality in developing countries.
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PMID: 26162850
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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HATZ, Christoph F R et al. Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study. In: Vaccine, 2015, vol. 33, n° 36, p. 4594-4601. https://archive-ouverte.unige.ch/unige:76361

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Deposited on : 2015-10-22

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