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Title

Needle-free and adjuvant-free epicutaneous boosting of pertussis immunity: Preclinical proof of concept

Authors
Mondoulet, Lucie
Dhelft, Véronique
Pham, Hong Thai
Petre, Jean
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Published in Vaccine. 2015, vol. 33, no. 30, p. 3450-3455
Abstract The limited durability of pertussis vaccine-induced protection requires novel approaches to reactivate immunity and limit pertussis resurgence in older children and adults. We propose that periodic boosters could be delivered using a novel epicutaneous delivery system (Viaskin) to deliver optimized pertussis antigens such as genetically-detoxified pertussis toxin (rPT). To best mimic the human situation in which vaccine-induced memory cells persist, whereas antibodies wane, we developed a novel adoptive transfer murine model of pertussis immunity. This allowed demonstrating that a single application of Viaskin delivering rPT and/or pertactin and filamentous hemagglutinin effectively reactivates vaccine-induced pertussis immunity and protects against Bordetella pertussis challenge. Recalling pertussis immunity without needles nor adjuvant may considerably facilitate the acceptance and application of periodic boosters.
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PMID: 26067183
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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MASTELIC-GAVILLET, Beatris et al. Needle-free and adjuvant-free epicutaneous boosting of pertussis immunity: Preclinical proof of concept. In: Vaccine, 2015, vol. 33, n° 30, p. 3450-3455. https://archive-ouverte.unige.ch/unige:76358

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Deposited on : 2015-10-22

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