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Scientific article
English

Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?

Contributors

Lefèvre, Julien; Germanaud, David; Dubois, Jessica; Rousseau, François Jean Robert; de Macedo Santos, Ines; Angleys, Hugo; Mangin, Jean-François; Hüppi, Petra Susan; Girard, Nadine Evelyne Adrienne; De Guio, François

Published in

Cerebral cortex, vol. 26, no. 7, p. 3023-3035

Publication date

2016

Abstract

Magnetic resonance imaging has proved to be suitable and efficient for in vivo investigation of the early process of brain gyrification in fetuses and preterm newborns but the question remains as to whether cortical-related measurements derived from both cases are comparable or not. Indeed, the developmental folding trajectories drawn up from both populations have not been compared so far, neither from cross-sectional nor from longitudinal datasets. The present study aimed to compare features of cortical folding between healthy fetuses and early imaged preterm newborns on a cross-sectional basis, over a developmental period critical for the folding process (21-36 weeks of gestational age [GA]). A particular attention was carried out to reduce the methodological biases between the 2 populations. To provide an accurate group comparison, several global parameters characterizing the cortical morphometry were derived. In both groups, those metrics provided good proxies for the dramatic brain growth and cortical folding over this developmental period. Except for the cortical volume and the rate of sulci appearance, they depicted different trajectories in both groups suggesting that the transition from into ex utero has a visible impact on cortical morphology that is at least dependent on the GA at birth in preterm newborns.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LEFÈVRE, Julien et al. Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns? In: Cerebral cortex, 2016, vol. 26, n° 7, p. 3023–3035. doi: 10.1093/cercor/bhv123

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Article (Published version)

Identifiers

Journal ISSN

1047-3211
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Technical informations

Creation

17/09/2015 10:29:00

First validation

17/09/2015 10:29:00

Update

14/03/2023 23:44:13

Status update

14/03/2023 23:44:13

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