Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome

Korff, Christian; Brunklaus, Andreas; Zuberi, Sameer M

doi:10.1111/epi.13105

Scientific article

English

Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome

Contributors

Korff, Christian

; Brunklaus, Andreas; Zuberi, Sameer M

Published in

Epilepsia, vol. 56, no. 10, p. 1477-1481

Publication date

2015

Abstract

The concept of epileptic encephalopathy is important in clinical practice, but its relevance to an individual must be assessed in the appropriate context. Except in rare situations, epileptic activity is a surrogate for an underlying etiology, and stopping the activity has a limited impact on developmental outcome. Labeling a group of epilepsies as "the epileptic encephalopathies," risks minimizing the impact of epileptic activity on cognition and behavior more widely in epilepsy. Similarly, describing the encephalopathy associated with many infantile onset epilepsies as "epileptic" may be misleading. Finally, concentrating on the epileptic activity alone and not considering the wider consequences of the underlying etiology on cognitive and behavioral development, may focus research efforts and the search for improved therapies on too narrow a target. Therefore, epileptic encephalopathies should not be considered as a specific group of epilepsies but, rather, the concept of epileptic encephalopathy should be applicable to all types of epilepsies and epilepsy syndromes, whenever it is relevant in the clinical course of a particular individual, at any age.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Citation (ISO format)

KORFF, Christian, BRUNKLAUS, Andreas, ZUBERI, Sameer M. Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome. In: Epilepsia, 2015, vol. 56, n° 10, p. 1477–1481. doi: 10.1111/epi.13105

Article (Published version)

Identifiers

PID : unige:76335
DOI : 10.1111/epi.13105
PMID : 26293471

Journal ISSN

0013-9580

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Creation

16/09/2015 14:54:00

First validation

16/09/2015 14:54:00

Update

14/03/2023 23:44:06

Status update

14/03/2023 23:44:06

Last indexation

31/10/2024 01:37:47

Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation