Scientific article

Liver biopsy in children: position paper of the ESPGHAN Hepatology Committee

Published inJournal of pediatric gastroenterology and nutrition, vol. 60, no. 3, p. 408-420
Publication date2015

Liver biopsy (LB) is still the criterion standard procedure for obtaining liver tissue for histopathological examination and a valuable tool in the diagnosis, prognosis, and management of many parenchymal liver diseases. The aim of this position paper is to summarise the present practice of paediatric LB and make recommendations about its performance. Although histological evaluation of the liver is important in assessing prognosis and exploring treatment, noninvasive techniques (ie, imaging, laboratory markers) may replace use of liver histology. The indications for LB are changing as present knowledge of aetiologies, pathomechanism, and therapeutic options in paediatric liver disease is evolving. Adult and paediatric literature was reviewed to assess the existing clinical practice of LB with focus on the technique, indications, risk of complications, and contraindications in paediatrics. This position paper presents types of LB, indications, complications, contraindications, and an essential checklist for paediatric LB.

Citation (ISO format)
DEZSŐFI, Antal et al. Liver biopsy in children: position paper of the ESPGHAN Hepatology Committee. In: Journal of pediatric gastroenterology and nutrition, 2015, vol. 60, n° 3, p. 408–420. doi: 10.1097/MPG.0000000000000632
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Article (Published version)
ISSN of the journal0277-2116

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