Physical properties and composition of oreforming fluids in magmatic-hydrothermal systems have been mainly characterized by studies of fluid inclusions in gangue minerals. Direct analyses of inclusion fluids trapped in ore minerals (pyrite, enargite, sphalerite, stibnite, wolframite) can be performed using near-infrared (NIR) microthermometry in combination with LA-ICP-MS analyses of individual inclusions. This study compares properties of fluid inclusions hosted in co-genetic ore (pyrite, stibnite, wolframite, enargite, sphalerite) and gangue (quartz, rhodochrosite) minerals from two magmatic-hydrothermal systems with fluid temperatures and salinities between 150° and 350°C, and 0.5 and 6 wt.% NaCl eq., respectively. Microthermometry reveals no difference in temperature and salinity records of fluid inclusions between host minerals. LA-ICP-MS analyses yield identical alkali concentrations for co-genetic ore and gangue mineral-hosted fluid inclusions, whereas chalcophile elements are strongly enriched in sulfidehosted fluid inclusions due to the presence of trapped solids attached to primary fluid inclusion cavities, or of daughter minerals that precipitate in the fluid inclusion following entrapment.