UNIGE document Scientific Article
previous document  unige:7621  next document
add to browser collection
Title

False serologic evidence for acute primary toxoplasmosis during liver transplantation for fulminant hepatitis B: a case report

Authors
Mentha, G.
Published in Transplantation Proceedings. 2009, vol. 41, no. 10, p. 4425-4427
Abstract Acute primary Toxoplasma gondii infection is usually considered to be a contraindication for solid organ transplantation. Recent reports of acute T. gondii infection have highlighted the need to include T. gondii serology in the pretransplant screening of solid-organ transplant recipients. However such serology might be misleading. We describe the case of a 25-year-old woman who received a liver transplantation for life-threatening liver failure due to hepatitis B virus infection. The presence of high IgM titers against T. gondii, as detected by membrane immunoassay, immunofluorescence, and mu-capture ELISA tests, together with the absence of IgG antibodies in the immediate pretransplant serology screening suggested acute primary T. gondii infection at the time of transplantation. We initiated a preemptive therapy with intravenous clindamycin and cotrimoxazole. However, negative PCR and IgA capture assays, together with the absence of a sustained IgG response finally excluded the initial diagnosis of primary toxoplasmosis, leading to discontinuation of antitoxoplasmosis therapy. This case illustrates the problem that, in the context of fulminant hepatitis B, serologic markers for acute primary toxoplasmosis can be falsely positive. Confirmation by PCR and IgA antibody determinations is required to confirm this diagnosis.
Identifiers
PMID: 20005415
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
UCKAY, Ilker et al. False serologic evidence for acute primary toxoplasmosis during liver transplantation for fulminant hepatitis B: a case report. In: Transplantation Proceedings, 2009, vol. 41, n° 10, p. 4425-4427. https://archive-ouverte.unige.ch/unige:7621

176 hits

0 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :