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Management of Gram-positive bacteraemia

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Published in Current Opinion in Infectious Diseases. 2007, vol. 20, no. 6, p. 561-567
Abstract PURPOSE OF REVIEW: Gram-positive bacteraemic infections are frequent and associated with high morbidity and mortality. This paper reviews publications focusing exclusively on new findings related to Gram-positive bacteraemia in the published literature from July 2006 to June 2007. RECENT FINDINGS: Ninety-eight articles have been reviewed. Of the 66 incorporated in this review, 21 focused on epidemiology or prevention. Thirty-two concerned staphylococcal bacteraemia, while 11 addressed other Gram-positive pathogens. There were seven articles on daptomycin, nine on endocarditis, seven on diagnostic issues, five on haemodialysis-related bacteraemia, and four on antibiotic lock techniques. SUMMARY: In contrast to the large amount of articles dealing with epidemiological issues, the past year did not reveal any new fundamental insights into the treatment of Gram-positive bacteraemia. The rise in the minimal inhibitory concentrations of Staphylococcus aureus to vancomycin may become a threat. Several publications underlined the in-vivo efficacy of daptomycin, the new kid on the block against Gram-positive bacteraemia and endocarditis. The antibiotic lock technique showed some promising potential for secondary prevention or treatment of catheter-related infection, while rapid molecular techniques for early species identification may become a valuable diagnostic tool. Most evidence was not based on large, randomized trials and needs future confirmation.
Keywords Anti-Bacterial Agents/ therapeutic useBacteremia/ drug therapyGram-Positive Bacterial Infections/ drug therapyHumans
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PMID: 17975404
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Research groups Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
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UCKAY, Ilker, HARBARTH, Stéphan Juergen, PITTET, Didier. Management of Gram-positive bacteraemia. In: Current Opinion in Infectious Diseases, 2007, vol. 20, n° 6, p. 561-567. https://archive-ouverte.unige.ch/unige:7618

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Deposited on : 2010-06-21

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